This page continues the Berberine Data Center with source records 101–145 of 145. It is an evidence directory: reviews and companion analyses are not additional independent trials. Source check: 22 October 2026.
Metabolism: clinical and experimental · 2008 · Pilot randomized comparison plus separate uncontrolled add-on cohort
An early pilot reported lower glucose and HbA1c in both a randomized comparison and a separate add-on cohort. Similar changes to metformin in a small pilot do not establish therapeutic equivalence.
Metabolism: clinical and experimental · 2010 · Human intervention with separate preclinical experiments
Clinical glucose changes accompanied increased insulin-receptor expression in circulating lymphocytes. Separate cultured-cell experiments explored the receptor pathway.
Talanta · 2010 · Companion clinical metabolomics analysis
Serum profiling identified changes in free fatty acids after berberine exposure. This is a mechanistic metabolomics report, not a new demonstration of improved clinical outcomes.
Phytomedicine : international journal of phytotherapy and phytopharmacology · 2012 · Exploratory human intervention
The uncontrolled human pilot reported modest weight loss and lower blood lipids. The publication also contains animal work, which is separate from its human observations.
Nature medicine · 2004 · Human intervention with separate preclinical experiments
This foundational report links lower human cholesterol with laboratory evidence of LDL-receptor regulation. The mechanistic component supports plausibility, while the small human component has limited causal certainty.
Metabolism: clinical and experimental · 2008 · Human intervention with separate preclinical experiments
The combination lowered lipids more than either monotherapy in a small clinical comparison, with separate receptor-mechanism experiments.
Expert opinion on biological therapy · 2013 · Double-blind placebo-controlled withdrawal and reintroduction trial
Lipid measurements improved during berberine exposure, worsened after withdrawal, and improved after reintroduction.
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine · 2016 · Randomized controlled human trial
This controlled trial reported lipid-profile improvement during berberine treatment in mild hyperlipidemia.
Frontiers in endocrinology · 2026 · Retrospective case-control analysis
Retrospective records suggested metabolic and inflammatory improvements with adjunctive berberine. Several anthropometric differences appeared only after statistical adjustment.
NPJ cardiovascular health · 2026 · Trial-signature, cohort and Mendelian-randomization analysis
A signature derived from berberine response was associated with cardiometabolic disease risk in observational and genetic analyses.
Clinical and experimental pharmacology & physiology · 2012 · Controlled adjunctive clinical biomarker study
Selected inflammatory markers declined more with adjunctive treatment after PCI. Lipid differences were not statistically significant.
European journal of pharmacology · 2009 · Exploratory human intervention
Endothelial microparticles declined alongside improved flow-mediated dilation in a small human study. Cell experiments explored a possible nitric-oxide pathway.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica · 2016 · Randomized controlled human trial
The report described selected inflammatory, plaque and neurological improvements with adjunctive berberine.
BMC genomics · 2022 · Exploratory clinical transcriptomics study
This very small transcriptomic comparison identified candidate RNA pathways linked to berberine exposure.
Medical oncology (Northwood, London, England) · 2010 · Two small randomized supportive-care comparisons plus case series
The report found fewer or less severe acute intestinal symptoms during radiotherapy.
European journal of cancer (Oxford, England : 1990) · 2008 · Double-blind randomized radiotherapy supportive-care trial
The trial reported less radiation-related lung injury and selected biomarker changes.
The Journal of infectious diseases · 1987 · Randomized controlled human trial
Berberine reduced selected ETEC diarrhea measures, while cholera effects were limited and adding it to tetracycline did not improve stool output.
British medical journal (Clinical research ed.) · 1985 · Double-blind randomized factorial trial
Tetracycline-containing treatment improved cholera outcomes. Berberine did not consistently improve clinical diarrhea outcomes, and neither agent outperformed placebo in the non-cholera subgroup.
Methods and findings in experimental and clinical pharmacology · 2006 · Two small healthy-volunteer interaction studies
Interaction results differed by cyclosporine regimen: exposure increased in one experiment but not the other.
Oxidative medicine and cellular longevity · 2021 · Systematic review and meta-analysis
The review reported improvements in glucose, insulin-resistance and lipid measures with berberine alone or alongside standard therapy.
Frontiers in pharmacology · 2021 · Systematic review and meta-analysis
This review focused on berberine used alone and reported metabolic signals across glucose, insulin resistance and lipids.
Evidence-based complementary and alternative medicine : eCAM · 2012 · Systematic review and meta-analysis
The early diabetes synthesis found glycemic and lipid signals but judged trial quality generally low. Comparisons with glucose-lowering medicines did not establish superiority.
Journal of ethnopharmacology · 2015 · Systematic review and meta-analysis
The review evaluated diabetes, lipids and blood pressure across several comparator and add-on subgroups.
Frontiers in nutrition · 2022 · Systematic review and meta-analysis
The dose-response synthesis reported selected lipid, glycemic and body-size changes across adult trials.
Phytomedicine : international journal of phytotherapy and phytopharmacology · 2018 · Systematic review and meta-analysis
The review found lipid improvements but explicitly identified high clinical heterogeneity and generally low methodological quality.
The American journal of Chinese medicine · 2019 · Systematic review and meta-analysis
The synthesis distinguished placebo, simvastatin and add-on comparisons and reported selected lipid improvements. Constipation was an adverse-event concern.
Journal of medicinal food · 2020 · Systematic review and meta-analysis
This synthesis examined plain and combination preparations without statin-like components. It reported lipid changes that differed by formulation.
Planta medica · 2013 · Systematic review and meta-analysis
The early synthesis reported lower cholesterol and triglycerides, with a small HDL change.
Phytomedicine : international journal of phytotherapy and phytopharmacology · 2023 · Systematic review and meta-analysis
The review reported selected inflammatory, neurological and plaque-related signals. Lipid comparisons for berberine alone versus routine therapy/statins were not consistently significant.
Pharmaceutical biology · 2023 · Systematic review and meta-analysis
Adjunctive berberine showed a signal for ventricular ectopy outcomes, while berberine alone did not clearly outperform antiarrhythmic comparators.
International journal of molecular sciences · 2024 · Systematic review and meta-analysis
The review mapped liver-related mechanisms and earlier clinical findings, with most included studies being experimental.
Evidence-based complementary and alternative medicine : eCAM · 2016 · Systematic review and meta-analysis
The historical synthesis reported selected lipid, glucose and liver-enzyme changes in NAFLD.
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · 2021 · Systematic review and meta-analysis
The review reported inconsistent weight-related results and selected insulin/hormonal signals.
Evidence-based complementary and alternative medicine : eCAM · 2018 · Systematic review and meta-analysis
Berberine did not clearly outperform metformin on several metabolic/reproductive measures, and add-on findings were inconsistent.
Therapeutic advances in gastroenterology · 2020 · Systematic review and meta-analysis
The review reported diarrhea-related signals but emphasized low or very low certainty for many outcomes. Most pediatric trials used rectal administration.
Frontiers in pharmacology · 2019 · Systematic review and meta-analysis
Adding berberine to standard triple therapy improved pooled eradication and symptom measures in the included Chinese trials.
Evidence-based complementary and alternative medicine : eCAM · 2018 · Systematic review and meta-analysis
The review found improved eradication and fewer selected treatment-related adverse effects when berberine was added to triple therapy.
Phytotherapy research : PTR · 2023 · Systematic review and meta-analysis
Pooled IL-6, TNF-alpha and CRP measures were lower after berberine/barberry interventions.
Complementary therapies in medicine · 2019 · Systematic review and meta-analysis
This narrow synthesis reported lower CRP with berberine across a small collection of trials.
PloS one · 2026 · Systematic review and meta-analysis
This review combined probiotic, synbiotic and berberine evidence and included exploratory enzyme-binding simulations.
Global advances in health and medicine · 2014 · Retrospective observational comparison of patient-selected treatments
Negative follow-up lactulose breath test in 17/37 herbal users and 23/67 rifaximin users; between-group difference was not statistically significant.
Phytotherapy research : PTR · 2019 · Systematic review and random-effects meta-analysis
The pooled analysis reported improved glucose and lipid markers for the combination, including a mean LDL difference of about -29.1 mg/dL.
PloS one · 2018 · Preclinical acute and repeated-dose pharmacokinetic study
After a single dose in rats, topical berberine and especially topical dihydroberberine increased measured berberine exposure relative to oral berberine. At day 14, the dihydroberberine formulation retained higher circulating exposure, while topical berberine performed less well. These were proprietary formulations, not human consumer-patch trials.
Frontiers in pharmacology · 2018 · Narrative botanical and pharmacology review
Berberine occurrence depends on species and plant tissue; the paper reviews botanical sources and extraction rather than a standardized dietary food-content database.
Frontiers in pharmacology · 2023 · Published randomized-trial protocol; not an outcome report
The protocol specifies a breath-test endpoint and a non-inferiority design. It provides no efficacy results.
