Tier 2 — strong

The effect and safety of Berberine on polycystic ovary syndrome: a systematic review

Mirzaee F, Razmjouei P, Shahrahmani H, Vafisani F, Najaf Najafi M, Ghazanfarpour M
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 2021 41(5):684-689

Bibliography

PubMed
PMID 32811221
DOI
10.1080/01443615.2020.1787964
Funding
Funding was not established from the accessible source; this is not a declaration of no funding.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignSystematic review and meta-analysis
ModelPublished human studies
SampleClinical PCOS studies; exact total not specified in abstract
InterventionEvidence synthesis; interventions and comparators vary across included studies
DurationNo new treatment; included-study durations vary
EndpointsPooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

What the study showed, in plain terms

The review reported inconsistent weight-related results and selected insulin/hormonal signals.

Key findings

  • The review reported inconsistent weight-related results and selected insulin/hormonal signals.

What this study can and cannot tell us

Heterogeneous formulations and methods; later integrity reassessment affects interpretation of this historical literature.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

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Citation network

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Editorial review

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology