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Berberine Combined with Triple Therapy versus Triple Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Randomized Controlled Trials

Jiang X, Jiang C, Huang C, Chen G, Jiang K, Huang B, Liu F

Evidence-based complementary and alternative medicine : eCAM 2018 2018:8716910

Bibliography

PubMed: PMID 30410559
PubMed Central: PMC6207132
DOI: 10.1155/2018/8716910
Funding: Funding was not established from the accessible source; this is not a declaration of no funding.
Competing interests: The authors declared no competing interests in the publication.

Design	Systematic review and meta-analysis
Model	Published human studies
Sample	Randomized adult eradication trials; see full review for denominator
Intervention	Evidence synthesis; interventions and comparators vary across included studies
Duration	No new treatment; included-study durations vary
Endpoints	Pooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

The review found improved eradication and fewer selected treatment-related adverse effects when berberine was added to triple therapy.

The review found improved eradication and fewer selected treatment-related adverse effects when berberine was added to triple therapy.

Older regimens and geographic concentration; no berberine-monotherapy conclusion follows.

Editorial review

Last verified 22 October 2026