Product Review

DoNotAge Pure Fisetin Review

5/5 Editorial scoreRECOMMENDED

5/5 editorial recommendation for a simple, 400 mg plant-derived fisetin capsule with a vegan shell and no fillers. Human longevity benefits remain unproven.

Fisetin, 400 mg per capsule

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By Dr. Khaled Mahmoud, MBBCh

Reviewed by Dr. Abdulla Mostafa, PhD, Dr. Amr Yasser, PhD

· 14 min read

How we scored it

Our editorial recommendation uses a 1–5 scale. We consider the formulation, label clarity, manufacturer quality disclosures, practical use and value for the intended reader. The published rating is an overall editorial judgment; these factors are not separately measured or weighted.

5/5 means a top editorial recommendation for the stated use case. It does not establish clinical effectiveness or mean that we performed laboratory testing. Research strength and safety limitations are assessed separately in this review.

5/5: our top editorial recommendation for a simple, high-strength fisetin capsule. We favor its 400 mg dose, vegan formula, no fillers and manufacturer quality disclosures. This is an editorial judgment, not proof of human benefit or an independent laboratory assessment.

Read the review summary

A review of DoNotAge's 400 mg fisetin capsules, manufacturer-reported quality standards and practical pack choices. The standalone bottle contains 60 capsules; annual plans use 366-capsule containers. Product specifications, clinical research and our editorial recommendation are assessed separately.

5/5 editorial recommendation for a simple, 400 mg plant-derived fisetin capsule with a vegan shell and no fillers. Human longevity benefits remain unproven.

Evidence for an ingredient does not establish the effects of this finished product. See the evidence section for study design, dose and limitations.

DoNotAge Pure Fisetin annual container: 366 capsules, 400 mg per capsule; standalone bottles contain 60 capsules View image

DoNotAge Pure Fisetin annual container: 366 capsules, 400 mg per capsule; standalone bottles contain 60 capsules

Read the full editorial assessment

DoNotAge Pure Fisetin receives our 5/5 editorial recommendation for readers seeking a straightforward, high-strength fisetin capsule. Each capsule provides 400 mg; DoNotAge recommends 800 mg daily. The supplied manufacturer page describes plant-derived fisetin, vegan HPMC capsules with no fillers, in-house and third-party testing, and GMP/ISO9001 quality standards. These quality statements are manufacturer-reported, and Biohack Blueprint has not independently assayed the current retail lot. Our recommendation reflects formulation, dose clarity, manufacturer disclosures and practical use. It does not establish that this retail product clears senescent cells, improves cognition or extends human healthspan. Those clinical questions retain their separate evidence grades.

Formulation strengths and limitations

Key takeaways

  • Fisetin's senolytic mechanism — selectively clearing senescent cells — is one of the best-replicated actions of any natural compound in this class, though confirmed human trial endpoints are still pending.
  • DoNotAge recommends 800 mg/day continuously, while most published human senolytic protocols use intermittent higher-dose schedules. No head-to-head trial has established that one strategy is clinically superior.
  • The product uses a simple standard HPMC capsule with no fillers. Enhanced-delivery fisetin products exist, but human trials have not established superior clinical outcomes for those formulations.
  • DoNotAge currently states that Pure Fisetin is verified through in-house testing and third-party lab testing, with GMP and ISO9001 manufacturing standards and a clean vegan formula.
Physician-reviewed 5/5 editorial recommendation 23 cited sources 400 mg per capsule Plant-derived, per manufacturer Manufacturer testing disclosures BB10: eligible standalone products

Formulation

Key facts & composition

View product label
Active ingredient Fisetin, 400 mg per capsule DoNotAge states its ingredients are verified to a 99.8% purity standard.
Dose per capsule 400 mg
Manufacturer's daily serving 800 mg (2 capsules) Manufacturer label guidance, not an established human senolytic or longevity dose. Follow the current label and seek individual advice when taking medication.
Format Vegan HPMC capsule, no fillers Plant-based capsule shell, free from animal-derived ingredients
Sourcing Plant-derived / naturally sourced fisetin DoNotAge currently describes Pure Fisetin as derived from natural plant sources and selected for stability and purity.
Testing status In-house + third-party testing stated DoNotAge describes in-house checks and third-party lab testing, plus GMP and ISO9001 quality standards. These are manufacturer disclosures; this review does not independently verify the current retail batch.
Pack formats 60-capsule standalone bottle; 366-capsule annual containers At 800 mg/day, a 60-capsule bottle lasts 30 days. The annual 400 mg/day plan uses one 366-capsule container; the 800 mg/day plan uses two. The main image shows the annual container.

Composition

Ingredient Amount Form Source
Fisetin 800 mg (two 400 mg capsules) Free-form fisetin in a standard capsule, no absorption-enhancing technology Plant-derived fisetin from natural plant sources, according to DoNotAge.

DoNotAge describes a standard fisetin capsule with a vegan HPMC shell and no fillers. Its source page does not identify a proprietary absorption-enhancing formulation. The plant-derived sourcing statement is manufacturer-reported; Biohack Blueprint has not independently assayed the current retail lot.

Who this is for

Good fit if you're...

Longevity-focused adults wanting a straightforward high-dose option

If you want a simple, single-ingredient fisetin supplement at a meaningfully high per-capsule dose without juggling several smaller capsules, this fits the brief directly.

People who want a clean, allergen-free capsule

The vegan HPMC capsule with no fillers suits anyone avoiding common allergens or animal-derived ingredients in their supplement stack.

People already buying other DoNotAge longevity supplements

If NMN or Ca-AKG are already part of your routine, adding fisetin from the same manufacturer keeps sourcing and quality standards consistent across your stack.

People who prefer a daily routine over a pulsed schedule

If remembering a once-every-28-days pulsed protocol feels impractical, a straightforward daily capsule is easier to build into a routine — with the trade-off explained in the pharmacology section above.

Probably not for you if...

Those wanting to replicate the exact clinical-trial protocol

Consider waiting and researching a weight-based pulsed protocol instead if your goal is specifically to match the dosing schedule used in published human trials.

Pregnant or breastfeeding women

No human safety data exists for this population, so fisetin supplementation isn't recommended here.

Those specifically seeking an absorption-enhanced formulation

Consider a liposomal or absorption-blend fisetin product instead if maximising bioavailability from the capsule itself is your main priority.

How it works

In selected laboratory and animal models, fisetin can eliminate some senescent cells, modulate inflammatory signals and influence oxidative-stress pathways. No completed trial has established systemic senescent-cell clearance from routine oral fisetin in humans. The following sections distinguish experimentally demonstrated pathways from clinical outcomes.

1

Clearing senescent cells

As we age, some cells stop dividing but refuse to die. These "senescent" cells build up in tissue and pump out inflammatory signals that damage the cells around them. Fisetin appears to nudge these cells towards a natural death process, sparing healthy cells nearby [1] [2]. This selective clearing effect, sometimes called senolysis, is the reason fisetin is grouped with a small class of compounds known as senolytics.

2

Calming the inflammatory signals senescent cells release

Senescent cells don't just sit quietly — they release a cocktail of inflammatory chemicals known as the senescence-associated secretory phenotype, or SASP. This SASP output is thought to spread low-grade inflammation to healthy neighbouring tissue. Fisetin has been shown to dial down key inflammatory signalling pathways, including NF-κB, in cell and animal models [17] [4], which may help contain this knock-on effect.

3

Defending cells against oxidative stress

Separately from its senolytic action, fisetin acts as an antioxidant. It appears to support the body's own antioxidant defences, including glutathione levels, and to activate protective pathways such as Nrf2 signalling [11] [13]. This gives it a second, complementary route to protecting cells from everyday wear and tear, on top of clearing out the ones that are already damaged.

Research & evidence

23 cited sources · Fisetin Data Center

The evidence

Sources include research papers and other cited records, such as registered trials. A trial registration is not a published result.

Each claim below is graded from A to D based on the strength and consistency of the evidence behind it, not on how promising the underlying idea sounds. A Grade D claim isn't a weak product — it usually reflects a young field where the right human trial simply hasn't reported yet.

A Fisetin selectively clears senescent cells in preclinical models Tier 2

This is one of the most consistently replicated actions of any natural compound in this class. Independent research groups have shown the same selective effect on senescent cells across multiple animal models and cell types [1] [2] [4], and it was this body of work that first identified fisetin as a senolytic candidate worth testing in people.

One honest caveat worth naming: the NIA's Interventions Testing Program — arguably the single most rigorous senescence test run on fisetin, spanning three independent US sites — measured the senescent-cell marker p16 directly in liver, kidney, and brain of treated mice and found no significant reduction on either a continuous or a pulsed dosing schedule [21]. That does not erase the broader body of positive clearance findings above, but it is a genuine null result from the field's most tightly controlled protocol, and an honest evidence page should carry it alongside the positive studies.

Yousefzadeh MJ et al. 2018 , Tavenier J et al. 2024 , Zhang L et al. 2020

B Fisetin reduces inflammatory and oxidative-stress markers Tier 2

Cell and animal studies consistently show fisetin dampening inflammatory signalling and supporting antioxidant defences across several tissue types [17] [11] [13]. A 2026 human RCT has now closed part of that gap: 60 obese men taking fisetin 200 mg/day for 12 weeks, combined with structured exercise, showed real reductions in IL-6 and TNF-alpha alongside improved insulin resistance (HOMA-IR), reported across two companion papers from the same trial [22] [23]. That is a single trial in one specific population (obese men, not the general population this product targets), not yet independently replicated — so it moves this claim from mechanism-only to genuine single-RCT human evidence, without yet justifying a top grade.

Kim SC et al. 2012 , Maher P 2009 , Shia CS et al. 2009 , Alipour M et al. 2026 , Alipour M et al. 2026

C Fisetin supports cognitive and neuroprotective function Tier 3

Animal studies link fisetin to better memory performance and protection against neurotoxic injury [11] [12], and the mechanism (reduced oxidative stress and inflammation in brain tissue) is plausible. This is a single-study-per-model evidence base rather than a replicated human finding, so treat the cognitive claim as promising rather than proven.

Maher P 2009 , Prakash D et al. 2015

C Fisetin may support vascular and arterial health with age Tier 3

In aged mice, clearing senescent cells with fisetin improved arterial function, using both genetic and pharmacological senolysis to confirm the effect [10]. This is a well-designed animal study, but it is currently the only one of its kind for this specific outcome, so the grade reflects a single-study evidence base rather than any doubt about the underlying mechanism.

Mahoney SA et al. 2023

B Most oral fisetin is absorbed poorly and converted into less-active forms Tier 3

Pharmacokinetic studies consistently show that fisetin taken by mouth is rapidly converted into sulphate and glucuronide conjugates, which are weaker antioxidants than fisetin itself [13] [16] [15]. This is well-documented, reproducible pharmacology — it's the reason formulation and delivery method genuinely matter for this ingredient, whichever brand you buy it from.

Shia CS et al. 2009 , Touil YS et al. 2011 , Ragelle H et al. 2012

D Confirmed human healthspan or lifespan extension from oral fisetin Tier 4

No completed human trial has yet reported that oral fisetin extends healthspan or lifespan. Several relevant trials are actively running or recently completed — AFFIRM, PROFFi and the Fisetin HIGH pilot among them [5] [6] [7] — but this is a structural feature of the entire senolytic field rather than a weakness specific to fisetin: human ageing trials with hard endpoints take years to report. The Grade D here reflects where the evidence currently stands, not a knock against the mechanism.

AFFIRM Trial 2018 (registered trial, not yet peer-reviewed), PROFFi Trial 2023 (registered trial, not yet peer-reviewed), Andersen O 2024 (registered trial, not yet peer-reviewed)

Scientific evidence was last checked on 27 September 2026 against 23 cited research records. Product details were corrected on 21 October 2026 using the supplied DoNotAge source page, including pack formats, plant-derived sourcing and return conditions. Manufacturer quality claims are not an independent assay of the current retail lot.

Comparison

How it compares

DoNotAge Pure Fisetin SupplementDoctor's Best Fisetin ProHealth Longevity Fisetin Pro
Dose per capsule 400 mg 100 mg 125 mg
Recommended daily dose 800 mg, every day (continuous) 100 mg, every day (continuous) 125–250 mg, every day (continuous)
Absorption-enhancing technology None — standard capsule None — standard capsule Yes — polyphenol/MCT oil absorption blend
Testing transparency In-house + third-party lab testing stated Not stated Third-party testing / certificate availability stated
Manufacturing certification GMP and ISO 9001-compliant Not stated FDA-registered, GMP-certified facility
Allergen and dietary claims Vegan, allergen-free, no fillers Vegan, non-GMO, gluten and soy-free Free of 10 major allergens, vegetable capsule
Return policy 14 days from delivery: full refund unopened; 50% refund if opened with at least 50% remaining. Satisfaction guarantee stated, no timeframe published 100 days

Clinical pharmacology

DoNotAge lists 400 mg per capsule and an 800 mg standard daily serving. Its label guidance is distinct from investigational human regimens: AFFIRM, PROFFi and Fisetin HIGH are studying intermittent schedules [5] [6] [7]. Other human studies use lower continuous doses or different pulse lengths. No trial has established a universal anti-aging or human senolytic dose.

At the manufacturer's standard 800 mg/day serving, 28 days would provide 22.4 g of fisetin. For comparison, a two-day 20 mg/kg research pulse would provide 2.8 g in a 70 kg trial participant. These totals are arithmetic illustrations, not equivalent blood exposure or evidence that either schedule is effective or safe for self-treatment.

The optimal frequency, formulation, human target-tissue exposure and long-term safety remain unresolved. Research pulse schedules are not consumer dosing instructions; follow the current product label and obtain individual medical advice when taking medicines or managing a health condition.

Dose tiers

TierDoseFrequencyDurationNotes
Starter (400 mg/day) 400 mg/day (1 capsule) Once daily Ongoing, daily

DoNotAge's lower continuous-dosing option — half the dose of their standard recommendation.
Standard (800 mg/day) 800 mg/day (2 capsules) Once daily (both capsules together) Ongoing, daily

DoNotAge's default recommended dose — this is the option most customers are directed towards, and it is dosed every day rather than in pulses.

From bench to bedside

PathwayPreclinical findingHuman translationConfidence
Senolysis (clearing senescent cells) In mice, fisetin selectively triggers the death of senescent cells across multiple tissues, reducing markers of cellular ageing and, in some models, extending healthy lifespan. Human trials testing whether the same clearance happens in people — including AFFIRM, PROFFi and the Fisetin HIGH pilot — are underway or recently completed, but full peer-reviewed results confirming senescent-cell clearance in humans are not yet published. Emerging
Inflammatory signalling (SASP suppression) Cell and animal studies show fisetin lowers NF-κB-driven inflammatory signalling and the broader senescence-associated secretory phenotype. This mechanism is well established in the lab. Whether daily supplemental fisetin measurably lowers inflammatory markers in healthy or frail older adults over months of use has not yet been directly confirmed in a published human trial. Emerging
Vascular and arterial ageing In old mice, clearing senescent cells with fisetin restored healthier arterial function, using both drug and genetic approaches to confirm the effect was really down to senescent-cell removal. This is a single, well-controlled animal study rather than a replicated finding, and no human vascular-function trial of oral fisetin has yet reported results. Early

Drug interactions

Not applicable

None formally established

No clinically significant drug interaction has been confirmed for fisetin in human studies to date. As a flavonoid, it is theoretically plausible fisetin could affect drug-metabolising enzymes or platelet function at high doses, but this hasn't been directly shown in people.

Recommendation:

Tell your doctor you're taking fisetin, particularly if you take blood thinners or any prescription medication with a narrow safety margin, so they can factor it in.

Bioavailability tips

Fisetin is poorly water-soluble, and preclinical studies demonstrate extensive metabolism [13] [16]. A small human crossover study demonstrated improved plasma exposure from a specific hybrid-hydrogel formulation, but both study arms were administered after an overnight fast. No controlled human trial has established that a fatty meal, morning dosing, or split dosing improves ordinary fisetin absorption or clinical outcomes. Follow the product label, and see our bioavailability evidence review for the formulation-specific data.

Special populations

PopulationRecommendationRationale
Pregnancy and breastfeeding Not recommended

No human safety data exists for fisetin supplementation during pregnancy or breastfeeding, so it isn't possible to rule out risk.
People taking blood-thinning medication Speak to your doctor before starting

Flavonoids can theoretically affect how platelets work. No specific interaction with fisetin has been confirmed, but this is a sensible check before combining it with anticoagulant or antiplatelet medication.
Frail older adults with multiple health conditions Best used with medical guidance

This is the population most senolytic research is actually aimed at — trials such as the Fisetin HIGH pilot specifically enrol older adults with multimorbidity [7] — but it's also the group most likely to be on multiple medications, so a quick conversation with a doctor or pharmacist first is worthwhile.

Therapeutic positioning

Fisetin sits within a small, fast-moving field of senolytic compounds and longevity interventions. Here's how it compares to the main alternatives.

Quercetin + Dasatinib (D+Q)

Prescription-adjacent senolytic combination Supervised, more studied

D+Q is the most-studied senolytic combination in early human trials, pairing a prescription cancer drug with the flavonoid quercetin. It has a larger, more advanced human evidence base than fisetin, but dasatinib is a repurposed chemotherapy agent with its own side-effect profile and typically requires medical supervision.

Quercetin (alone)

Related dietary flavonoid Weaker standalone evidence

Quercetin is fisetin's closest chemical relative and is often discussed alongside it, but on its own quercetin has shown weaker senolytic activity in head-to-head lab comparisons than fisetin.

NAD+ precursors (NMN, NR)

Different longevity mechanism Complementary, not competing

NMN and NR aim to restore falling NAD+ levels and support cellular energy metabolism — a different biological target from senescent-cell clearance entirely.

Caloric restriction and fasting-mimicking diets

Lifestyle intervention Foundation, not a substitute

Sustained caloric restriction is one of the most robust lifespan-extending interventions in animal research, and some of its benefit is thought to run through reduced cellular senescence — but it is difficult to sustain and not appropriate for everyone.

Neither fisetin nor any of the other supplements compared here replaces foundational health measures such as regular physical activity, sufficient sleep, diet quality and evidence-based medical care. Fisetin remains an investigational longevity supplement, not a proven healthspan treatment.

This supplement is not a replacement for medical treatment, a balanced diet, or regular exercise, and it has not been evaluated to diagnose, treat, cure or prevent any disease.

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About buying through us

Why trust this review over DoNotAge's own product page?

DoNotAge's product page is designed to showcase Pure Fisetin at its best — that's exactly what a manufacturer's own page should do. This review serves a different purpose: it's written independently by a physician, with every claim graded against the published research and checked directly against two named competitor products, so you have an independent second opinion to weigh alongside DoNotAge's own page, not instead of it.

Does Biohack Blueprint sell or ship this product?

No. We hold no inventory and don't process orders. DoNotAge handles manufacturing, fulfilment and customer service directly. We're an independent editorial review that earns a commission if you buy through our link, at no extra cost to you.

How is the reader discount code funded?

The BB10 code is our DoNotAge Discount Code, provided by DoNotAge as part of our affiliate partnership. Using it doesn't cost you anything extra, and it doesn't change the independence of the editorial content above — the evidence grades and comparison table are the same whether or not you use the code.

Why isn't there a price shown on this page?

Because we don't sell the product, we don't display pricing — prices and any subscription terms are set and shown by DoNotAge directly on their own site.

Who wrote and reviewed this analysis?

This review is authored by Dr Khaled Mahmoud, and reviewed for accuracy by Dr Amr Yasser and Dr Abdulla Mostafa, whose domains between them cover fisetin's bioavailability, safety and cellular senescence biology. Their credentials are listed in the byline below.

Reader questions

What is fisetin and where does it come from?

Fisetin is a plant flavonoid found naturally in foods such as strawberries, apples, persimmons and cucumbers. DoNotAge currently describes its Pure Fisetin as plant-derived / naturally sourced rather than a synthetic fisetin product. Its senolytic potential is still being tested in human studies, so the product should not be treated as clinically proven to clear senescent cells in people.

How much fisetin should I take, and how do I take it?

DoNotAge recommends 800 mg per day (two 400 mg capsules), taken continuously. That's a different approach from the pulsed protocol used in most published human trials — see the dosing discrepancy explained in the pharmacology section above before deciding what's right for you.

Is fisetin safe to take every day, or only in pulses?

Published human trials have generally used a pulsed schedule — a higher dose on two consecutive days, repeated roughly every 28 days [5] [6] — rather than continuous daily dosing. Long-term continuous daily use at these dose levels hasn't been directly studied in the same way, so this is a genuine open question rather than a settled one.

Can I take fisetin with other supplements or medication?

No clinically significant drug interaction has been confirmed for fisetin. It's commonly paired with other longevity supplements such as NMN or Ca-AKG. If you're on blood-thinning medication or any prescription drug with a narrow safety margin, mention fisetin to your doctor first.

How long does it take before fisetin starts working?

Fisetin's proposed mechanism — clearing senescent cells and calming the inflammation they cause — is a slow, biological process rather than something you'd feel immediately. Most research protocols run for weeks to months before assessing outcomes, so plan for a similar timeframe rather than expecting a quick, noticeable change.

Editorial credibility

Portrait of Dr. Khaled Mahmoud, ICU physician and founder of Biohack Blueprint

Author

Dr. Khaled Mahmoud, MBBCh

MBBCh

Critical Care Medicine, Longevity Science & Editorial Direction

Portrait of Dr. Abdulla Mostafa, neuroscience reviewer for Biohack Blueprint

Reviewer

Dr. Abdulla Mostafa, PhD

MBBCh, PhD, Neuroscience, Neurosurgery

Cellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology

Portrait of Dr. Amr Yasser, cardiometabolic and musculoskeletal reviewer for Biohack Blueprint

Reviewer

Dr. Amr Yasser, PhD

MBBCh, PhD, General Surgery, Cardiometabolic Medicine, Musculoskeletal Research

Cardiometabolic, Musculoskeletal, Gut & Bioavailability

5/5: our top editorial recommendation for a simple, high-strength fisetin capsule. We favor its 400 mg dose, vegan formula, no fillers and manufacturer quality disclosures. This is an editorial judgment, not proof of human benefit or an independent laboratory assessment.

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Related reading

Fisetin: A Clinician's Guide to Evidence, Dose & Safety

What Is Fisetin? Structure, Sources, and How It Works

Fisetin Benefits: What the Evidence Actually Shows

Fisetin Senolytic: Does It Clear Senescent Cells in Humans?

Fisetin Dosage: What Human Studies Actually Use

How and When to Take Fisetin

Fisetin Pulse Dosing: What Human Trials Actually Use

Fisetin Bioavailability: The Flavonoid Absorption Problem

Liposomal Fisetin: Does the Formulation Actually Matter?

Foods High in Fisetin: Natural Sources Ranked

Fisetin Side Effects and Safety: What the Trials Show (2026)

Fisetin Drug Interactions: What to Watch For (2026)

Fisetin and Blood Pressure: Does It Raise or Lower It?

Fisetin in Pregnancy and Breastfeeding: What We Know (2026)

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Fisetin vs Quercetin: Which Is Better, and When to Combine (2026)

Fisetin vs Spermidine: Two Different Longevity Bets (2026)

Fisetin vs Urolithin A: Senolytic vs Mitophagy (2026)

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Fisetin for Skin: Antioxidant, Senolytic, and Topical

Fisetin for Hair Growth and Grey Hair: The Honest Evidence (2026)

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Best Fisetin Supplement (2026): The Complete Buyer's Guide
  1. Fisetin is a senotherapeutic that extends health and lifespan Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ (2018) . EBioMedicine Read on our Data CenterView on PubMed View on PMC DOI
  2. Fisetin as a senotherapeutic agent — evidence and perspectives for age-related diseases Tavenier J, Nehlin JO, Houlind MB, Rasmussen LJ, Tchkonia T, Kirkland JL, Andersen O, Rasmussen LJH (2024) . Mechanisms of Ageing and Development Read on our Data CenterView on PubMed DOI
  3. Targeting Cellular Senescence with Liposome-Encapsulated Fisetin: Evidence of Senomorphic Effect Henschke A, Grześkowiak B, Ivashchenko O, Sánchez-Cerviño MC, Coy E, Moya S (2025) . International Journal of Molecular Sciences Read on our Data CenterView on PubMed View on PMC DOI
  4. Fisetin Alleviated Bleomycin-Induced Pulmonary Fibrosis Partly by Rescuing Alveolar Epithelial Cells From Senescence Zhang L, Tong X, Huang J, Wu M, Zhang S, Wang D, Liu S, Fan H (2020) . Frontiers in Pharmacology Read on our Data CenterView on PubMed View on PMC DOI
  5. Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Women (AFFIRM) AFFIRM Trial (2018) . ClinicalTrials.gov (trial registry record — not yet published in a peer-reviewed journal) Read on our Data Center Clinical Trial
  6. Prevention of Frailty With Fisetin and Exercise in Breast Cancer Survivors (PROFFi) PROFFi Trial (2023) . Not applicable - trial registered on ClinicalTrials.gov (not yet published in a peer-reviewed journal) Read on our Data Center Clinical Trial
  7. Pilot Trial of Fisetin in Healthy Volunteers and Older Patients With Multimorbidity (Fisetin HIGH) Andersen O (2024) . Not applicable - trial registered on ClinicalTrials.gov (not yet published in a peer-reviewed journal) Read on our Data Center Clinical Trial
  8. Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study Illathu Madhavamenon Krishnakumar, Asha Jaja-Chimedza, Ashil Joseph, Abhilash Balakrishnan, Balu Maliakel, Andrew Swick (2022) . Journal of Nutritional Science Read on our Data CenterView on PubMed View on PMC DOI Clinical Trial
  9. Fisetin for COVID-19 in skilled nursing facilities: Senolytic trials in the COVID era Brandon P. Verdoorn, Tamara K. Evans, Gregory J. Hanson, Yi Zhu, Larissa G. P. Langhi Prata, Robert J. Pignolo, Elizabeth J. Atkinson, Erin O. Wissler-Gerdes, George A. Kuchel, Joan B. Mannick, Stephen B. Kritchevsky, Sundeep Khosla, Stacey A. Rizza, Jeremy D. Walston, Nicolas Musi, Lewis A. Lipsitz, Douglas P. Kiel, Raymond Yung, Nathan K. LeBrasseur, Ravinder J. Singh, Teresa McCarthy, Michael A. Puskarich, Laura J. Niedernhofer, Paul D. Robbins, Matthew Sorenson, Tamara Tchkonia, James L. Kirkland (2021) . Journal of the American Geriatrics Society Read on our Data CenterView on PubMed View on PMC DOI Clinical Trial
  10. Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence Mahoney SA, Venkatasubramanian R, Darrah MA, Ludwig KR, VanDongen NS, Greenberg NT, Longtine AG, Hutton DA, Brunt VE, Campisi J, Melov S, Seals DR, Rossman MJ, Clayton ZS (2023) . Aging Cell Read on our Data CenterView on PubMed View on PMC DOI
  11. Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin Maher P (2009) . Genes & Nutrition Read on our Data CenterView on PubMed View on PMC DOI
  12. Dietary flavonoid fisetin regulates aluminium chloride-induced neuronal apoptosis in cortex and hippocampus of mice brain Prakash D, Sudhandiran G (2015) . The Journal of Nutritional Biochemistry Read on our Data CenterView on PubMed DOI
  13. Metabolism and pharmacokinetics of 3,3',4',7-tetrahydroxyflavone (fisetin), 5-hydroxyflavone, and 7-hydroxyflavone and antihemolysis effects of fisetin and its serum metabolites Shia CS, Tsai SY, Kuo SC, Hou YC, Chao PD (2009) . Journal of Agricultural and Food Chemistry Read on our Data CenterView on PubMed DOI
  14. Japanese intake of flavonoids and isoflavonoids from foods Kimira M, Arai Y, Shimoi K, Watanabe S (1998) . Journal of Epidemiology Read on our Data CenterView on PubMed DOI
  15. Nanoemulsion formulation of fisetin improves bioavailability and antitumour activity in mice Ragelle H, Crauste-Manciet S, Seguin J, Brossard D, Scherman D, Arnaud P, Chabot GG (2012) . International Journal of Pharmaceutics Read on our Data CenterView on PubMed DOI
  16. Fisetin disposition and metabolism in mice: Identification of geraldol as an active metabolite Touil YS, Auzeil N, Boulinguez F, Saighi H, Regazzetti A, Scherman D, Chabot GG (2011) . Biochemical Pharmacology Read on our Data CenterView on PubMed DOI
  17. Inhibition of c-Jun N-terminal kinase and nuclear factor κ B pathways mediates fisetin-exerted anti-inflammatory activity in lipopolysaccharide-treated RAW264.7 cells Kim SC, Kang SH, Jeong SJ, Kim SH, Ko HS, Kim SH (2012) . Immunopharmacology and Immunotoxicology Read on our Data CenterView on PubMed DOI
  18. Fisetin Promotes Hair Growth by Augmenting TERT Expression Chisato Kubo, Mizuki Ogawa, Norihisa Uehara, Yoshinori Katakura (2020) . Frontiers in Cell and Developmental Biology Read on our Data CenterView on PubMed View on PMC DOI
  19. New Perspectives for Fisetin Grynkiewicz G, Demchuk OM (2019) . Frontiers in Chemistry Read on our Data CenterView on PubMed View on PMC DOI
  20. Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches Kevin O. Murray, Sophia A. Mahoney, Katelyn R. Ludwig, Jill H. Miyamoto-Ditmon, Nicholas S. VanDongen, Nirad Banskota, Allison B. Herman, Douglas R. Seals, Robert T. Mankowski, Matthew J. Rossman, Zachary S. Clayton (2025) . Aging Cell Read on our Data CenterView on PubMed View on PMC DOI
  21. Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used Harrison DE, Strong R, Reifsnyder P, Rosenthal N, Korstanje R, Fernandez E, Flurkey K, Ginsburg BC, Murrell MD, Javors MA, Lopez-Cruzan M, Nelson JF, Willcox BJ, Allsopp R, Watumull DM, Watumull DG, Cortopassi G, Kirkland JL, Tchkonia T, Choi YG, Yousefzadeh MJ, Robbins PD, Mitchell JR, Acar M, Sarnoski EA, Bene MR, Salmon A, Kumar N, Miller RA (2024) . GeroScience Read on our Data CenterView on PubMed View on PMC DOI
  22. 12-weeks fisetin supplementation and interval resistance with aerobic training: changes in Maresin-1 and inflammatory markers in men with obesity: a randomized controlled trial Alipour M, Saeidi A, Hejazi K, Laher I, Zouhal H (2026) . Journal of the International Society of Sports Nutrition Read on our Data CenterView on PubMed View on PMC DOI Clinical Trial
  23. The Effects of Interval Resistance-Aerobic Training and Fisetin Supplementation on Asprosin and Selected Adipokines in Obese Men: A Double-Blind Randomized Control Trial Alipour M, Saeidi A, Hejazi K, Supriya R, Zouhal H (2026) . Nutrients Read on our Data CenterView on PubMed View on PMC DOI Clinical Trial
  • 2 Sep 2026 Initial publication: full physician review with 20 cited papers, evidence grading, live-verified comparison against Doctor's Best Fisetin and ProHealth Longevity Fisetin Pro.
  • 21 Sep 2026 Updated manufacturer sourcing and quality statements, and refreshed links to supporting fisetin research and reader guides.
  • 27 Sep 2026 Updated to reflect the 120-entry fisetin evidence library and newly indexed 2025 knee-osteoarthritis and 2026 lung-disease conference abstracts. Clarified human trial dosing, supplement safety and uncertainty about meal timing or fat-assisted absorption; refreshed product image descriptions.
  • 21 Oct 2026 Clarified 60-capsule and annual pack formats, corrected the composition sourcing statement to plant-derived, and added return conditions from the supplied manufacturer page. Updated the editorial recommendation to 5/5 and explained its scope. Scientific evidence retains its separate verification date.
First published 2 Sep 2026 · Last verified 27 Sep 2026