The evidence base for calcium alpha-ketoglutarate

Calcium alpha-ketoglutarate (Ca-AKG) is the calcium salt of α-ketoglutarate, a Krebs cycle intermediate that sits at the crossroads of energy metabolism, amino acid handling, ammonia detoxification, and — through the histone demethylase family it acts as a cofactor for — the epigenome. In the past decade α-ketoglutarate has moved from being a niche renal-pharmacology compound to one of the most-discussed molecules in longevity research, driven by lifespan and healthspan findings in worms, flies, and mice, and by a widely-reported observational study of a proprietary formulation and DNA methylation age. This page is the audit trail for what the peer-reviewed literature actually shows. Every paper below has been read against its source PDF and verified against PubMed. Findings are reported at the tier the underlying study design warrants — no promotion, no dose extrapolation, no manufacturer positioning.