Tier 2 — strong

Protective effects of berberine on radiation-induced lung injury via intercellular adhesion molecular-1 and transforming growth factor-beta-1 in patients with lung cancer

Liu Y, Yu H, Zhang C, Cheng Y, Hu L, Meng X, Zhao Y

European journal of cancer (Oxford, England : 1990) 2008 44(16):2425-2432

Bibliography

PubMed: PMID 18789680
DOI: 10.1016/j.ejca.2008.07.040
Funding: Funding was not established from the accessible source; this is not a declaration of no funding.
Competing interests: A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Design	Double-blind randomized radiotherapy supportive-care trial
Model	Human participants; see population
Sample	90 lung-cancer patients enrolled; 85 completed
Intervention	Berberine with radiotherapy versus placebo with radiotherapy
Duration	6-week treatment; lung assessments through 6 months
Endpoints	Radiation-related lung injury; Pulmonary function; sICAM-1 and TGF-beta1

The trial reported less radiation-related lung injury and selected biomarker changes.

The trial reported less radiation-related lung injury and selected biomarker changes.

Small historical supportive-care study; does not establish antitumor efficacy or safety with all modern oncology regimens.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

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Last verified 22 October 2026