Tier 2 — strong

Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension

Lan J, Zhao Y, Dong F, Yan Z, Zheng W, Fan J, Sun G
Journal of ethnopharmacology 2015 161:69-81

Bibliography

PubMed
PMID 25498346
Funding
Indexed support: Natural Science Foundation of Zhejiang Province; Wenzhou Municipal 551 Talented Grant; Zhejiang Province Chinese Medicine Scientific Research Fund; Wenzhou Traditional Chinese Medicine Laboratory Center; Wenzhou Science & Technology Bureau of Grant; Wenzhou and Wenzhou Municipal Health Bureau of Grant. See the publication for grant details.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignSystematic review and meta-analysis
ModelPublished human studies
Sample27 randomized trials; 2569 participants
InterventionEvidence synthesis; interventions and comparators vary across included studies
DurationNo new treatment; included-study durations vary
EndpointsPooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

What the study showed, in plain terms

The review evaluated diabetes, lipids and blood pressure across several comparator and add-on subgroups.

Key findings

  • The review evaluated diabetes, lipids and blood pressure across several comparator and add-on subgroups.

What this study can and cannot tell us

Historical, heterogeneous evidence; a nonsignificant difference against a medicine is not proof of equivalence.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

Editorial review

Reviewed by the Biohack Blueprint research team

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