Tier 2 — strong

[Effects of berberine on serum inflammatory factors and carotid atherosclerotic plaques in patients with acute cerebral ischemic stroke]

Li Y, Wang P, Chai MJ, Yang F, Li HS, Zhao J, Wang H, Lu DD
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 2016 41(21):4066-4071

Bibliography

PubMed
PMID 28929697
Funding
Funding was not established from the accessible source; this is not a declaration of no funding.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignRandomized controlled human trial
ModelHuman participants; see population
Sample120 acute ischemic stroke patients
InterventionBerberine 300 mg three times/day plus standard care versus standard care
DurationInflammation at 14 days; plaque and disability outcomes at 90 days
EndpointsCardiac or vascular outcomes; Inflammatory biomarkers; Adverse events

What the study showed, in plain terms

The report described selected inflammatory, plaque and neurological improvements with adjunctive berberine.

Key findings

  • The report described selected inflammatory, plaque and neurological improvements with adjunctive berberine.

What this study can and cannot tell us

Limited reporting and a single clinical setting; it does not establish a role in replacing acute stroke therapy.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

Editorial review

Reviewed by the Biohack Blueprint research team

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