Tier 4 — mechanistic

Effect of berberine on global modulation of lncRNAs and mRNAs expression profiles in patients with stable coronary heart disease

Han YC, Xie HZ, Lu B, Xiang RL, Li JY, Qian H, Zhang SY
BMC genomics 2022 23(1):400

Bibliography

PubMed
PMID 35619068
PubMed Central
PMC9134690
DOI
10.1186/s12864-022-08641-2
Funding
Supported by the Chinese Academy of Medical Sciences Innovation Fund, grant 2016-I2M-1-011.
Competing interests
The authors declared no competing interests in the publication.

Study snapshot

DesignExploratory clinical transcriptomics study
ModelHuman participants; see population
Sample5 berberine-exposed CHD patients and 5 unexposed volunteers
InterventionWhole-blood RNA profiling with validation analyses
DurationSampling interval not established from abstract
EndpointsDifferential lncRNA/mRNA expression; Pathway and network analyses; qPCR validation

What the study showed, in plain terms

This very small transcriptomic comparison identified candidate RNA pathways linked to berberine exposure.

Key findings

  • This very small transcriptomic comparison identified candidate RNA pathways linked to berberine exposure.

What this study can and cannot tell us

Ten-person molecular comparison, multiple testing and potential confounding; not an efficacy trial.

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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology