Data Center
A first-party research corpus, clinician-led and evidence-tiered. Browse every supplement Data Center, inspect its paper count, and open the underlying evidence map.
Supplements in the corpus
Search the directory or open any supplement to inspect its research corpus.
Fisetin
A dietary flavonol studied as a candidate senotherapeutic. Senolytic activity is established in selected cell and animal models; systemic senescent-cell clearance and longevity benefits in humans remain unproven.
Quercetin
290 source-linked publications on quercetin, with human evidence, safety, formulations and experimental context. Browse the complete research library from the overview.
SIRT6 Activator
SIRT6 evidence library covering molecular structure and allosteric regulation, DNA repair, lifespan biology, sex-specific aging, human biomarkers, natural and synthetic activators, clinical trials, fucoidan translation, and context-dependent disease biology across cancer, inflammation, lung, cardiovascular, endothelial, renal, metabolic, adipose, musculoskeletal, neurological, intestinal and skin systems.
Calcium alpha-ketoglutarate
Ca-AKG has decades of human exposure data and extensive aging biology, but human longevity efficacy is unproven. Mouse lifespan findings conflict, circulating AKG does not show a consistently established age-related decline in humans, and related AKG salts have distinct pharmacology.
Creatine
An 89-paper creatine evidence library spanning dosing, performance, muscle and body composition, safety, kidneys, women, menopause, older adults, cognition, sleep deprivation, plant-based diets, creatine forms, caffeine and supplement interactions, rehabilitation, recovery and selected clinical applications.
NAC
An 89-paper NAC evidence library covering oral pharmacokinetics, glutathione, exercise performance and recovery, training adaptation, GlyNAC and aging, COPD and bronchiectasis, psychiatry and substance use, PCOS and fertility, endometriosis, acetaminophen toxicity, acute liver failure, pregnancy, MASLD, obesity, sleep apnea, autism, ADHD-related symptom research, topical acne, safety, drug interactions, kidney outcomes and cancer-related research.
Sulforaphane
A formulation-first human evidence library covering sulforaphane pharmacokinetics, myrosinase-dependent conversion, food preparation, safety, pollution and tobacco-exposure biomarkers, metabolic disease and prediabetes, autism and schizophrenia trials, respiratory biology, H. pylori research and cancer-related randomized evidence. The central editorial rule is simple: delivered sulforaphane exposure and the exact human endpoint matter more than broccoli-extract milligrams or pathway marketing.
Nitric Oxide
The signalling molecule behind vasodilation, oxygen delivery, and endothelial repair. Papers cover the L-arginine, L-citrulline, and dietary nitrate pathways, plus the vascular, cognitive, and performance endpoints that shift as endogenous production falls with age.
Hydrolysed collagen peptides
Hydrolysed collagen evidence library with 85 verified research records: human peptide absorption; conflicting skin meta-analyses and funding/quality sensitivity; formulation-specific joint and bone trials; resistance-training and tendon evidence; collagen-versus-whey muscle-protein studies; preliminary gut research; and human hydroxyproline–oxalate safety data. Trials apply to the exact preparations studied, not automatically to every collagen powder or DoNotAge's finished product.
NMN
A direct NAD+ precursor studied for target engagement, metabolic and vascular outcomes, physical function, safety, and tissue-specific aging biology.
Nicotinamide Riboside
98 publications on NR bioavailability, human clinical outcomes, safety, NAD+ biomarker interpretation and key mechanistic research.
Berberine
145 source records on berberine: human metabolic and gut studies, formulations, interactions, safety, evidence reviews and experimental aging. Includes null findings, shared-cohort labels and corrections.
Spermidine
A 46-record spermidine evidence library spanning randomized human trials, safety, pharmacokinetics, cognition, immune aging, cardiovascular and mortality epidemiology, cancer context, food sources, reviews, autophagy and eIF5A-hypusination biology.
Vitamin D3, K2 & Magnesium
Human trials and evidence reviews on vitamin D3, K2 and magnesium, covering bone health, nutrient metabolism, aging, absorption, dosing and safety.
General & Cross-Cutting Evidence
Frameworks, biological-age clocks, biomarker consensus, label-accuracy analyses and finished-product trials — the cross-cutting evidence that governs how every other hub is read.
Urolithin A
A gut-microbiome-derived ellagitannin metabolite and direct postbiotic studied for mitophagy, muscle function, immune aging and mitochondrial quality control, with a growing human RCT and systematic-review evidence base.
CoQ10
A 103-paper CoQ10 evidence library spanning human trials, systematic reviews, safety and interaction reports, pharmacokinetics, formulation comparisons, dietary sources, cardiovascular health, migraine, fatigue, fertility, cognition, liver health, skin, hair, fibromyalgia, periodontal health, mitochondrial disorders and primary CoQ10 deficiency.
Resveratrol
A structured source-of-truth library for resveratrol covering human randomized trials, systematic reviews and meta-analyses, bioavailability and pharmacokinetics, dose and safety research, drug-interaction evidence, mechanistic studies and clearly separated preclinical longevity research.
Apigenin
A 67-paper apigenin evidence library spanning direct human pharmacokinetics and controlled feeding studies, human dietary-sleep observational evidence, a 2026 multi-ingredient bedtime RCT containing 50 mg apigenin, chamomile-based sleep and anxiety trials, GABA and benzodiazepine-receptor research, CD38/NAD+ biology, cellular senescence and senomorphic/SASP research, inflammation, neurobiology, cardiometabolic models, gut microbiota, formulation science, bioavailability, toxicology, safety and drug-interaction evidence. Human efficacy evidence for isolated apigenin remains limited and is kept separate from botanical, combination, observational and preclinical evidence.
Hyaluronic acid
A 36-record oral hyaluronic acid evidence library spanning modern skin meta-analysis and randomized trials, older primary skin studies, 2025 HA-matrix and full-spectrum formulations, dose and molecular-weight research, direct human safety, dry-eye evidence, knee discomfort and osteoarthritis studies, positive and null combination trials, low-back-pain evidence, and gut-microbiome/bioavailability mechanisms.
TMG (trimethylglycine)
415 source-linked publications on TMG and glycine betaine, with human evidence, safety, formulations and experimental context. Browse the complete research library from the overview.
Glycine
83 source-linked publications on glycine: human sleep studies, metabolism, muscle and clinical nutrition, cardiovascular risk, GlyNAC combinations, safety and experimental aging. Plain glycine, collagen and TMG remain distinct.
Editorial standards
Every paper page is built from verified PubMed metadata. Author names are copied from the source, and each paper is assigned an evidence tier reflecting its methodological strength.
Tier 1 covers multiple large human randomised controlled trials with consistent findings, or high-quality meta-analyses. Tier 2 covers a well-powered human RCT or comprehensive review of human data. Tier 3 covers preclinical animal studies or mechanistic in vitro work with translational relevance. Tier 4 covers early mechanistic, in silico, or hypothesis-generating findings.
Papers are reviewed by the Medical Advisory Board on a domain-matched basis. Preprints are flagged explicitly. Retracted papers are removed and their citations audited across editorial articles.
- Dr Khaled Mahmoud, MBBCh Editor-in-Chief
- Dr Abdulla Mostafa Abu Elsoud Neuroscience Reviewer
- Dr Amr Yasser Said Nassar Cardiometabolic Reviewer