Tier 4 — mechanistic

Berberine-induced decline in circulating CD31+/CD42- microparticles is associated with improvement of endothelial function in humans

Wang JM, Yang Z, Xu MG, Chen L, Wang Y, Su C, Tao J
European journal of pharmacology 2009 614(1-3):77-83

Bibliography

PubMed
PMID 19401197
DOI
10.1016/j.ejphar.2009.04.037
Funding
Funding was not established from the accessible source; this is not a declaration of no funding.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignExploratory human intervention
ModelHuman participants; see population
Sample14 berberine-treated healthy adults and 11 controls
InterventionBerberine 1.2 g/day; separate endothelial-cell experiments
Duration1 month
EndpointsCardiac or vascular outcomes; Inflammatory biomarkers; Adverse events

What the study showed, in plain terms

Endothelial microparticles declined alongside improved flow-mediated dilation in a small human study. Cell experiments explored a possible nitric-oxide pathway.

Key findings

  • Endothelial microparticles declined alongside improved flow-mediated dilation in a small human study. Cell experiments explored a possible nitric-oxide pathway.

What this study can and cannot tell us

Small nondefinitive clinical comparison; correlated biomarker changes do not establish clinical cardiovascular protection.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology