Tier 2 — strong

Clinical trial of berberine in acute watery diarrhoea

Khin-Maung-U, Myo-Khin, Nyunt-Nyunt-Wai, Aye-Kyaw, Tin-U
British medical journal (Clinical research ed.) 1985 291(6509):1601-1605

Bibliography

PubMed
PMID 3935203
PubMed Central
PMC1418442
DOI
10.1136/bmj.291.6509.1601
Funding
Funding was not established from the accessible source; this is not a declaration of no funding.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignDouble-blind randomized factorial trial
ModelHuman participants; see population
Sample400 adults; 185 with cholera and 215 without cholera
InterventionBerberine, tetracycline, combination or placebo
DurationAcute inpatient diarrhea trial
EndpointsEradication or stool-output outcomes; Treatment tolerability; Adherence

What the study showed, in plain terms

Tetracycline-containing treatment improved cholera outcomes. Berberine did not consistently improve clinical diarrhea outcomes, and neither agent outperformed placebo in the non-cholera subgroup.

Key findings

  • Tetracycline-containing treatment improved cholera outcomes. Berberine did not consistently improve clinical diarrhea outcomes, and neither agent outperformed placebo in the non-cholera subgroup.

What this study can and cannot tell us

Historical pathogen mix and complex factorial results; preserve the null clinical findings.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

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Editorial review

Reviewed by the Biohack Blueprint research team

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology