Tier 2 — strong

Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis

Dong H, Wang N, Zhao L, Lu F
Evidence-based complementary and alternative medicine : eCAM 2012 2012:591654

Bibliography

PubMed
PMID 23118793
PubMed Central
PMC3478874
DOI
10.1155/2012/591654
Funding
Indexed support: National Natural Science Foundation of China. See the publication for grant details.
Competing interests
The authors declared no competing interests in the publication.

Study snapshot

DesignSystematic review and meta-analysis
ModelPublished human studies
Sample14 randomized trials; 1068 participants
InterventionEvidence synthesis; interventions and comparators vary across included studies
DurationNo new treatment; included-study durations vary
EndpointsPooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

What the study showed, in plain terms

The early diabetes synthesis found glycemic and lipid signals but judged trial quality generally low. Comparisons with glucose-lowering medicines did not establish superiority.

Key findings

  • The early diabetes synthesis found glycemic and lipid signals but judged trial quality generally low. Comparisons with glucose-lowering medicines did not establish superiority.

What this study can and cannot tell us

Small, poorly reported studies and unclear bias; retained as historical evidence rather than the current final estimate.

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Editorial review

Reviewed by the Biohack Blueprint research team

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology