Tier 2 — strong

Efficacy and safety of berberine for several cardiovascular diseases: A systematic review and meta-analysis of randomized controlled trials

Yang L, Zhu W, Zhang X, Zhou X, Wu W, Shen T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 112:154716

Bibliography

PubMed
PMID 36805484
DOI
10.1016/j.phymed.2023.154716
Funding
Indexed support: National Natural Science Foundation of China; Science and Technology Department of Sichuan Province. See the publication for grant details.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignSystematic review and meta-analysis
ModelPublished human studies
Sample44 randomized trials; 4606 participants
InterventionEvidence synthesis; interventions and comparators vary across included studies
DurationNo new treatment; included-study durations vary
EndpointsPooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

What the study showed, in plain terms

The review reported selected inflammatory, neurological and plaque-related signals. Lipid comparisons for berberine alone versus routine therapy/statins were not consistently significant.

Key findings

  • The review reported selected inflammatory, neurological and plaque-related signals. Lipid comparisons for berberine alone versus routine therapy/statins were not consistently significant.

What this study can and cannot tell us

Heterogeneity and study quality limit certainty; surrogate changes should not be relabeled as fewer heart attacks or strokes.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology