Tier 2 — strong
Efficacy of berberine in patients with type 2 diabetes mellitus
Metabolism: clinical and experimental
2008
57(5):712-717
Bibliography
- PubMed
- PMID 18442638
- PubMed Central
- PMC2410097
- Funding
- Supported by Xinhua Hospital and NIH grant P50 AT02776-020002.
- Competing interests
- A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.
Study snapshot
| Design | Pilot randomized comparison plus separate uncontrolled add-on cohort |
|---|---|
| Model | Human participants; see population |
| Sample | 36 randomized in study A; 48 in a separate add-on study |
| Intervention | Berberine 500 mg three times/day; metformin comparator or add-on to prior treatment |
| Duration | 13 weeks (approximately 3 months) |
| Endpoints | Fasting and postload glucose; HbA1c and insulin sensitivity; Lipid profile and tolerability |
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