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Efficacy and safety of berberine for premature ventricular contractions: a meta-analysis and systematic review of randomized controlled trials

Qiao M, Lei C, Tan C, Lu C, Chen Z, Zhang Q, Wang Z

Pharmaceutical biology 2023 61(1):1474-1483

Bibliography

PubMed: PMID 37855412
PubMed Central: PMC10588516
DOI: 10.1080/13880209.2023.2248167
Funding: Reported funding sources: China Academy of Chinese Medical Sciences (CACMS) Innovation Fund10.13039/501100005892. Grant and funder-role details are in the publication.
Competing interests: The authors declared no competing interests in the publication.

Design	Systematic review and meta-analysis
Model	Published human studies
Sample	10 randomized trials; 896 participants
Intervention	Evidence synthesis; interventions and comparators vary across included studies
Duration	No new treatment; included-study durations vary
Endpoints	Pooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

Adjunctive berberine showed a signal for ventricular ectopy outcomes, while berberine alone did not clearly outperform antiarrhythmic comparators.

Adjunctive berberine showed a signal for ventricular ectopy outcomes, while berberine alone did not clearly outperform antiarrhythmic comparators.

Variable effective-rate definitions and limited safety ascertainment; this cannot exclude rare QT-related adverse events.

Editorial review

Last verified 22 October 2026