Tier 2 — strong

The effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis

Zamani M, Zarei M, Nikbaf-Shandiz M, Hosseini S, Shiraseb F, Asbaghi O
Frontiers in nutrition 2022 9:1013055

Bibliography

PubMed
PMID 36313096
PubMed Central
PMC9614282
Funding
Funding was not established from the accessible source; this is not a declaration of no funding.
Competing interests
The authors declared no competing interests in the publication.

Study snapshot

DesignSystematic review and meta-analysis
ModelPublished human studies
SampleAdult randomized trials; outcome-specific denominators vary
InterventionEvidence synthesis; interventions and comparators vary across included studies
DurationNo new treatment; included-study durations vary
EndpointsPooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

What the study showed, in plain terms

The dose-response synthesis reported selected lipid, glycemic and body-size changes across adult trials.

Key findings

  • The dose-response synthesis reported selected lipid, glycemic and body-size changes across adult trials.

What this study can and cannot tell us

Study-level dose curves are not validated prescribing rules. Mixed preparations and cointerventions constrain an alleged optimal dose.

Editorial review

Reviewed by the Biohack Blueprint research team

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