Tier 4 — mechanistic

Berberine ameliorates inflammation in patients with acute coronary syndrome following percutaneous coronary intervention

Meng S, Wang LS, Huang ZQ, Zhou Q, Sun YG, Cao JT, Li YG, Wang CQ
Clinical and experimental pharmacology & physiology 2012 39(5):406-411

Bibliography

PubMed
PMID 22220931
Funding
Funding was not established from the accessible source; this is not a declaration of no funding.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignControlled adjunctive clinical biomarker study
ModelHuman participants; see population
Sample130 ACS/PCI patients; 61 received adjunctive berberine
InterventionBerberine 300 mg three times/day plus standard care versus standard care
Duration30 days
EndpointsCardiac or vascular outcomes; Inflammatory biomarkers; Adverse events

What the study showed, in plain terms

Selected inflammatory markers declined more with adjunctive treatment after PCI. Lipid differences were not statistically significant.

Key findings

  • Selected inflammatory markers declined more with adjunctive treatment after PCI. Lipid differences were not statistically significant.

What this study can and cannot tell us

The abstract does not establish randomized allocation. Inflammation measurements do not establish fewer recurrent cardiac events.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

Editorial review

Reviewed by the Biohack Blueprint research team

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