Tier 2 — strong

Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials

Beba M, Djafarian K, Shab-Bidar S

Complementary therapies in medicine 2019 46:81-86

Bibliography

PubMed: PMID 31519292
DOI: 10.1016/j.ctim.2019.08.002
Funding: Funding was not established from the accessible source; this is not a declaration of no funding.
Competing interests: A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Design	Systematic review and meta-analysis
Model	Published human studies
Sample	5 studies
Intervention	Evidence synthesis; interventions and comparators vary across included studies
Duration	No new treatment; included-study durations vary
Endpoints	Pooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

This narrow synthesis reported lower CRP with berberine across a small collection of trials.

This narrow synthesis reported lower CRP with berberine across a small collection of trials.

Few studies, variable populations and a surrogate endpoint; overlapping later reviews are not independent replication.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

Editorial review

Last verified 22 October 2026