Best Ca-AKG supplement: a clinician's buying guide
Our #1 Ca-AKG supplement for 2026 is DoNotAge Ca-AKG, selected for its clean formulation, independent testing standards, practical dosing, established longevity focus and overall value.
Evidence library 24 analyses
Ca-AKG
A research hub for calcium alpha-ketoglutarate (Ca-AKG): longevity biology, human evidence, dosing, formulations and safety.
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All Ca-AKG analysis
Browse every published guide, review and evidence update in this topic.
Ca-AKG vs Urolithin A: human evidence and mechanisms compared
Ca-AKG vs Urolithin A in 2026: Urolithin A has more direct human mitochondrial/muscle data; Ca-AKG has observational biological-age evidence. Neither has proven longevity efficacy.
Ca-AKG vs NMN: mechanisms and human evidence compared
Ca-AKG vs NMN in 2026: NMN has stronger randomized NAD+ target-engagement data; Ca-AKG has an observational biological-age signal. Neither has proven human longevity efficacy.
Ca-AKG and fisetin: pairing a Krebs cycle metabolite with a senolytic
Ca-AKG and fisetin target different senescence-related biology, but no human trial has validated the combination. What senolytic versus senomorphic evidence actually supports.
Ca-AKG and cancer: the honest evidence check
Ca-AKG and cancer: preclinical colorectal and lymphoma suppression, IDH/2-HG oncometabolite biology, and why none of it proves cancer prevention or cancer risk in humans.
Ca-AKG dietary sources: foods that contain alpha-ketoglutarate
Ca-AKG foods explained: your body makes AKG, foods supply precursors rather than a validated supplement dose, and precise 'high-AKG food' tables are poorly standardized.
Ca-AKG side effects and safety profile
Ca-AKG side effects and safety reviewed against the human exposure record: mild GI effects, calcium load, drug-interaction gaps, kidney considerations and what long-term data still cannot answer.
Ca-AKG for weight loss and fatty liver: what the metabolic data supports
Ca-AKG for weight loss and fatty liver: middle-aged mouse obesity data, OXGR1 signaling, the 2024 fatty-liver study, and why human efficacy remains unproven.
Ca-AKG and inflammation: the SASP, cytokines and inflammaging picture
Ca-AKG and inflammation: SASP, TET signaling, macrophages, thromboinflammation and newer human immune-cell studies show a context-dependent immunometabolic effect—not a proven human anti-inflammatory benefit.