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Metabolic effect of berberine-silymarin association: A meta-analysis of randomized, double-blind, placebo-controlled clinical trials

Fogacci F, Grassi D, Rizzo M, Cicero AFG
Phytotherapy research : PTR 2019 33:862-870

Bibliography

PubMed
PMID 30632209
PubMed Central
PMC6590227
Funding
The paper states it was written independently.
Competing interests
The authors declare no conflict of interest.

Study snapshot

DesignSystematic review and random-effects meta-analysis
ModelPublished literature
Sample5 randomized trials; 497 participants
InterventionBerberine plus silymarin combinations versus control
DurationIncluded trials ranged from 3 months to 52 weeks
EndpointsTotal cholesterol; LDL cholesterol; HDL cholesterol; Triglycerides; Fasting plasma glucose

What the study showed, in plain terms

The pooled analysis reported improved glucose and lipid markers for the combination, including a mean LDL difference of about -29.1 mg/dL.

Key findings

The pooled analysis reported improved glucose and lipid markers for the combination, including a mean LDL difference of about -29.1 mg/dL.

What this study can and cannot tell us

Combination evidence does not establish the effect of plain berberine or prove synergy versus either ingredient alone. Trials, formulations and background treatment differed.

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