Tier 2 — strong

Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials

Ju J, Li J, Lin Q, Xu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 50:25-34

Bibliography

PubMed
PMID 30466986
DOI
10.1016/j.phymed.2018.09.212
Funding
Indexed support: National Clinical Research Centre of Traditional Chinese Medicine; Capital's Funds for Health Improvement and Research. See the publication for grant details.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignSystematic review and meta-analysis
ModelPublished human studies
Sample16 trials; 2147 participants
InterventionEvidence synthesis; interventions and comparators vary across included studies
DurationNo new treatment; included-study durations vary
EndpointsPooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

What the study showed, in plain terms

The review found lipid improvements but explicitly identified high clinical heterogeneity and generally low methodological quality.

Key findings

  • The review found lipid improvements but explicitly identified high clinical heterogeneity and generally low methodological quality.

What this study can and cannot tell us

Selection, masking, attrition and confounding concerns reduce confidence in pooled estimates.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology