Tier 2 — strong

Effects of berberine and barberry on selected inflammatory biomarkers in adults: A systematic review and dose-response meta-analysis of randomized clinical trials

Vahedi-Mazdabadi Y, Shahinfar H, Toushih M, Shidfar F
Phytotherapy research : PTR 2023 37(12):5541-5557

Bibliography

PubMed
PMID 37675930
DOI
10.1002/ptr.7998
Funding
Indexed support: Student Research Committee of the Iran University of Medical Sciences. See the publication for grant details.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignSystematic review and meta-analysis
ModelPublished human studies
Sample18 clinical trials; 1600 participants
InterventionEvidence synthesis; interventions and comparators vary across included studies
DurationNo new treatment; included-study durations vary
EndpointsPooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

What the study showed, in plain terms

Pooled IL-6, TNF-alpha and CRP measures were lower after berberine/barberry interventions.

Key findings

  • Pooled IL-6, TNF-alpha and CRP measures were lower after berberine/barberry interventions.

What this study can and cannot tell us

Barberry preparations are not isolated berberine. Inflammatory biomarker changes do not establish treatment of inflammatory disease.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

Related papers in the corpus

Tier 2
The effect of berberine on obesity indices: a systematic review and meta-analysis
Elahi Vahed I et al. · International journal of obesity (2005) · 2026
Tier 2
Adjunctive berberine for schizophrenia with metabolic syndrome: a systematic review and meta-analysis
Xie K et al. · Frontiers in psychiatry · 2026
Tier 2
The Integrative Role of Berberine in Gut Microbiota Modulation and Cardiometabolic Outcomes: A Systematic Review of Randomised Clinical Trials
Candrea AR et al. · Nutrients · 2026
Tier 2
Probiotics, synbiotics and berberine in Type 2 diabetes mellitus: A systematic review, meta-analysis, and molecular dynamics simulation study
Shadin M et al. · PloS one · 2026
Tier 2
Questionable Evidence for Berberine in Polyendocrine Metabolic Ovarian Syndrome: An Integrity-Based Reappraisal
Perera E et al. · Advances in therapy · 2026

Citation network

Articles citing this research paper

1 article

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology