Tier 2 — strong

The Efficacy of Berberine-Containing Quadruple Therapy on Helicobacter Pylori Eradication in China: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Hu Q, Peng Z, Li L, Zou X, Xu L, Gong J, Yi P
Frontiers in pharmacology 2019 10:1694

Bibliography

PubMed
PMID 32116685
PubMed Central
PMC7010642
DOI
10.3389/fphar.2019.01694
Funding
Supported by the National Natural Science Foundation of China, grant 81673757.
Competing interests
The authors declared no competing interests in the publication.

Study snapshot

DesignSystematic review and meta-analysis
ModelPublished human studies
Sample13 articles
InterventionEvidence synthesis; interventions and comparators vary across included studies
DurationNo new treatment; included-study durations vary
EndpointsPooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

What the study showed, in plain terms

Adding berberine to standard triple therapy improved pooled eradication and symptom measures in the included Chinese trials.

Key findings

  • Adding berberine to standard triple therapy improved pooled eradication and symptom measures in the included Chinese trials.

What this study can and cannot tell us

Antibiotics and acid suppression remain part of the tested regimen; regional resistance and study quality limit generalization.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology