The evidence base for fisetin
Fisetin is a flavonoid — a small plant molecule found in strawberries, apples, and onions — that has drawn scientific attention as a candidate senolytic. Senolytics selectively clear senescent cells, the aged and dysfunctional cells that accumulate with time and contribute to age-related disease. The fisetin evidence base spans mechanistic in vitro work, preclinical animal studies, and a small but growing set of human clinical trials.
Evidence at a glance
Cellular senescence
Fisetin is a senotherapeutic that extends health and lifespan
Preclinical mouse study across two models (Ercc1⁻/Δ progeroid and aged wild-type C57BL/6:FVB) with in vitro senolytic screening. Mechanistic depth is strong, but there is no direct human evidence in this paper.
Tier 2Fisetin as a senotherapeutic agent — evidence and perspectives for age-related diseases
Comprehensive narrative review synthesising in vitro evidence, animal model data, and results from published and ongoing phase I/II human clinical trials. Not primary data, but the most complete evidence assessment available in the fisetin senotherapeutic literature.