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The effects of berberine on the pharmacokinetics of cyclosporin A in healthy volunteers
Methods and findings in experimental and clinical pharmacology
2006
28(1):25-29
Bibliography
- PubMed
- PMID 16541194
- Funding
- Funding was not established from the accessible source; this is not a declaration of no funding.
- Competing interests
- A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.
Study snapshot
| Design | Two small healthy-volunteer interaction studies |
|---|---|
| Model | Human participants; see population |
| Sample | 12 healthy men in two six-person experiments |
| Intervention | Cyclosporine with repeated or single-dose berberine |
| Duration | 10-day repeated-dose experiment and separate acute comparison |
| Endpoints | Plasma exposure and pharmacokinetics; Drug interaction measurements; Short-term tolerability |
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