Tier 2 — strong

Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature

Ionita-Radu F, Patoni C, Nancoff AS, Marin FS, Gaman L, Bucurica A, Socol C, Jinga M, Dutu M, Bucurica S

International journal of molecular sciences 2024 25(8):4201

Bibliography

PubMed: PMID 38673787
PubMed Central: PMC11050387
DOI: 10.3390/ijms25084201
Funding: Indexed support: Carol Davila University of Medicine and Pharmacy through the institutional program Publish. See the publication for grant details.
Competing interests: The authors declared no competing interests in the publication.

Design	Systematic review and meta-analysis
Model	Nine clinical studies and 64 preclinical studies; analyzed as distinct evidence layers
Sample	73 studies: 9 clinical and 64 preclinical
Intervention	Evidence synthesis; interventions and comparators vary across included studies
Duration	No new treatment; included-study durations vary
Endpoints	Pooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

The review mapped liver-related mechanisms and earlier clinical findings, with most included studies being experimental.

The review mapped liver-related mechanisms and earlier clinical findings, with most included studies being experimental.

Clinical and animal results must remain separate; a large publication count is not a large human-trial corpus.

Editorial review

Last verified 22 October 2026