Senolytics Improve Physical Function and Increase Lifespan in Old Age
This study provides high-quality preclinical in vivo animal data combined with ex vivo mechanistic findings in human tissue explants.
Quercetin research
The evidence base for quercetin
Quercetin is a naturally occurring flavonoid found abundantly in apples, onions, and capers. It is heavily investigated in longevity science for its antioxidant, anti-inflammatory, and targeted senolytic properties. Recognized most prominently for its role in the D+Q (dasatinib and quercetin) senolytic protocol, it helps clear dysfunctional, pro-inflammatory cells from aging tissues. This hub archives the verified clinical and preclinical evidence defining its efficacy, safety, and exact biological mechanisms.
Evidence at a glance
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Cellular senescence
Sirtuins
Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives
Preclinical mechanistic study combining in vitro biochemistry, isoform-specific activity assays, and X-ray crystallography of SIRT6/quercetin and SIRT2/quercetin complexes. No human data.