Product Review

DoNotAge SulforaBoost® Review

5/5 Editorial score5/5 · #1 OVERALL

Our 5/5 #1 overall sulforaphane supplement pick for 2026. SulforaBoost pairs glucoraphanin with active myrosinase in a simple capsule, aligns with the best-established human bioavailability principle, and is supported by...

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By Dr. Khaled Mahmoud, MBBCh

Reviewed by Dr. Amr Yasser, PhD, Dr. Abdulla Mostafa, PhD

· 14 min read

How we scored it

Our editorial recommendation uses a 1–5 scale. We consider the formulation, label clarity, manufacturer quality disclosures, practical use and value for the intended reader. The published rating is an overall editorial judgment; these factors are not separately measured or weighted.

5/5 means a top editorial recommendation for the stated use case. It does not establish clinical effectiveness or mean that we performed laboratory testing. Research strength and safety limitations are assessed separately in this review.

5/5 and our #1 overall sulforaphane supplement pick for 2026: active myrosinase, a simple glucoraphanin-plus-enzyme formula, documented quality-control positioning, flexible dosing, BB10 value and our 37-paper evidence library.

Read the review summary

A clean glucoraphanin-plus-active-myrosinase formula, reviewed against the human sulforaphane literature rather than brand claims alone. The key question is not the milligram weight by itself—it is how much sulforaphane exposure the formulation can actually generate.

Our 5/5 #1 overall sulforaphane supplement pick for 2026. SulforaBoost pairs glucoraphanin with active myrosinase in a simple capsule, aligns with the best-established human bioavailability principle, and is supported by clear manufacturing and testing statements plus our 37-paper evidence library.

Evidence for an ingredient does not establish the effects of this finished product. See the evidence section for study design, dose and limitations.

DoNotAge SulforaBoost supplement with broccoli-seed glucoraphanin and active myrosinase View image

DoNotAge SulforaBoost supplement with broccoli-seed glucoraphanin and active myrosinase

Read the full editorial assessment

DoNotAge SulforaBoost® is our 5/5 #1 overall sulforaphane supplement pick for 2026. It combines glucoraphanin with active myrosinase, keeps the formula simple, supports practical dosing, and is backed by clear manufacturing and testing statements from DoNotAge. Its strongest advantage is the complete package: evidence-aligned delivery design, ingredient simplicity, quality-control positioning, flexible bottle sizes, BB10 value and direct integration with Biohack Blueprint’s 37-paper Sulforaphane evidence library.

Physician-authored 5/5 · #1 overall Active myrosinase 37-paper Data Center GMP & ISO9001 stated Vegan clean-label formula BB10 saves 10%

Who this is for

Good fit if you're...

Readers who want active myrosinase

Prioritizes precursor-to-sulforaphane conversion rather than precursor-only formulas.

Clean-formula shoppers

Wants glucoraphanin + myrosinase with a simple vegan capsule and no declared fillers.

Evidence-first buyers

Wants the commercial product connected to a transparent 37-paper evidence library.

DoNotAge shoppers

Can use BB10 on eligible standalone purchases.

How it works

SulforaBoost® is a precursor-plus-enzyme system rather than a capsule of stable free sulforaphane. Broccoli-seed glucoraphanin is converted to sulforaphane by myrosinase. Human bioavailability studies show that preserving or adding active myrosinase can materially increase sulforaphane exposure, so formulation is part of the effective dose. Sulforaphane can modify KEAP1–NRF2 signaling, but pathway activation is not equivalent to a clinical outcome.

Re-checked October 16, 2026 against DoNotAge’s current SulforaBoost page and the 37-paper Sulforaphane Data Center. DoNotAge states that SulforaBoost includes active myrosinase, GMP/ISO9001 production and batch testing/verification; this review cross-checks those product facts against the current human sulforaphane evidence base.

Comparison

How it compares

DoNotAge SulforaBoost® SupplementAvmacol Extra Strength Jarrow BroccoMax
Active myrosinase Yes Yes Yes
Core delivery system Glucoraphanin + active myrosinase Glucoraphanin + active myrosinase; plus Maitake Glucoraphanin + myrosinase system
Formula simplicity Two-component active system + capsule Adds Maitake mushroom extract Broccoli-seed system; check current label for excipients
Evidence framework 37-paper Biohack Blueprint evidence library + active-myrosinase formulation rationale Multiple branded human studies Established glucoraphanin + myrosinase formulation
Bioavailability logic Strong Strong Strong
Biohack Blueprint position 5/5 · #1 overall Leading active-myrosinase alternative Value alternative

Clinical pharmacology

The current SulforaBoost page describes 1–2 capsules daily; its 460 mg/day annual option corresponds to two 230 mg capsules. Those numbers describe the combined glucoraphanin/myrosinase formula, not 460 mg of free sulforaphane. The dose tiers below describe current product-use options rather than clinically validated sulforaphane-equivalent doses. Human studies use different preparations and report dose in different units, so simple milligram-to-milligram comparisons are often misleading.

Bioavailability tips

Active myrosinase is the critical formulation feature. Human crossover studies show that enzymatic conversion can materially raise sulforaphane exposure from glucoraphanin-rich preparations. Consistency of preparation matters more than chasing a large label milligram number; do not assume that precursor weight equals absorbed sulforaphane.

Therapeutic positioning

SulforaBoost ranks #1 overall for us because it combines active myrosinase, a short ingredient list, clear quality-control positioning, flexible bottle sizes, practical dosing and BB10 value. It is the strongest overall package in our 2026 sulforaphane comparison.

Broccoli sprouts and other cruciferous foods provide glucoraphanin and, when raw or lightly prepared, myrosinase. Food remains the nutritional baseline; supplements mainly offer convenience and more standardized exposure. Neither food nor a supplement should be treated as a substitute for established medical care.

SulforaBoost® is not a substitute for cancer treatment, diabetes care, psychiatric treatment, respiratory therapy, a balanced diet or clinician evaluation of persistent symptoms.

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Editorial credibility

Portrait of Dr. Khaled Mahmoud, ICU physician and founder of Biohack Blueprint

Author

Dr. Khaled Mahmoud, MBBCh

MBBCh

Critical Care Medicine, Longevity Science & Editorial Direction

Portrait of Dr. Amr Yasser, cardiometabolic and musculoskeletal reviewer for Biohack Blueprint

Reviewer

Dr. Amr Yasser, PhD

MBBCh, PhD, General Surgery, Cardiometabolic Medicine, Musculoskeletal Research

Cardiometabolic, Musculoskeletal, Gut & Bioavailability

Portrait of Dr. Abdulla Mostafa, neuroscience reviewer for Biohack Blueprint

Reviewer

Dr. Abdulla Mostafa, PhD

MBBCh, PhD, Neuroscience, Neurosurgery

Cellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology

5/5 and our #1 overall sulforaphane supplement pick for 2026: active myrosinase, a simple glucoraphanin-plus-enzyme formula, documented quality-control positioning, flexible dosing, BB10 value and our 37-paper evidence library.

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14-day return policy

Related reading

Sulforaphane Supplement Guide: Forms, Myrosinase & Human Evidence

Best Sulforaphane Supplements 2026: What Actually Delivers Sulforaphane?

Sulforaphane Benefits: Human Evidence Ranked by Strength (2026)

Sulforaphane Dosage: Human Trial Doses, µmol to mg & Myrosinase

Sulforaphane Side Effects & Safety: Human Data by Dose and Form

Foods High in Sulforaphane: Broccoli Sprouts, Cooking & Myrosinase

Sulforaphane vs Glucoraphanin: Conversion, Myrosinase & Labels

Myrosinase & Sulforaphane: The Enzyme That Controls Conversion

Broccoli Sprouts vs Sulforaphane Supplements: Human Absorption Compared

Sulforaphane & NRF2: What Human Trials Actually Show

Sulforaphane Bioavailability: Myrosinase, Absorption & What Reaches the Body

Sulforaphane Detoxification: What Human Pollution & Smoker Trials Show

Sulforaphane & Cancer: What Human Clinical Trials Actually Show

Sulforaphane & Autism: What RCTs and the 2025 Meta-Analyses Show

Sulforaphane & Blood Sugar: Diabetes, Prediabetes and Human RCTs
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  2. Sulforaphane — a compound with potential health benefits for disease prevention and treatment: insights from pharmacological and toxicological experimental studies Baralić K, Živanović J, Marić Đ, Božić D, Grahovac L, Antonijević Miljaković E, Ćurčić M, Buha Djordjevic A, Bulat Z, Antonijević B, Đukić-Ćosić D (2024) . Antioxidants Read on our Data CenterView on PubMed View on PMC DOI
  3. Sulforaphane as a potential therapeutic agent: a comprehensive analysis of clinical trials and mechanistic insights Atsushi Saito, Shoichi Ishikawa, Kun Yang, Akira Sawa, Koko Ishizuka (2025) . Journal of Nutritional Science Read on our Data CenterView on PubMed View on PMC DOI
  4. Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study Theresa A Shapiro, Jed W Fahey, Albena T Dinkova-Kostova, W David Holtzclaw, Katherine K Stephenson, Kristina L Wade, Lingxiang Ye, Paul Talalay (2006) . Nutrition and Cancer Read on our Data CenterView on PubMed DOI
  5. Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China Patricia A Egner, Jian Guo Chen, Jin Bing Wang, Yan Wu, Yan Sun, Jian Hua Lu, Jian Zhu, Yong Hui Zhang, Yong Sheng Chen, Marlin D Friesen, Lisa P Jacobson, Alvaro Muñoz, Derek Ng, Geng Sun Qian, Yuan Rong Zhu, Tao Yang Chen, Nigel P Botting, Qingzhi Zhang, Jed W Fahey, Paul Talalay, John D Groopman, Thomas W Kensler (2011) . Cancer Prevention Research Read on our Data CenterView on PubMed View on PMC DOI
  6. Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract Lauren L Atwell, Anna Hsu, Carmen P Wong, Jan F Stevens, Deborah Bella, Tian-Wei Yu, Clifford B Pereira, Christiane V Löhr, John Mark Christensen, Roderick H Dashwood, David E Williams, Jackilen Shannon, Emily Ho (2015) . Molecular Nutrition & Food Research Read on our Data CenterView on PubMed View on PMC DOI
  7. Exogenous myrosinase from mustard seed increases bioavailability of sulforaphane from a glucoraphanin-rich broccoli seed extract in a randomized clinical study Angela Mastaloudis, Lola Holcomb, Jed W Fahey, Camila Akemi Sakaguchi, David C Nieman, Colin Kay, Robert O'Donnell, Alessandra Pecorelli, Marissa Kinney, Yanyan Li, Suzanne L Ishaq, Giuseppe Valacchi (2026) . Scientific Reports Read on our Data CenterView on PubMed View on PMC DOI
  8. Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial Dionysios V Chartoumpekis, Panos G Ziros, Jian-Guo Chen, John D Groopman, Thomas W Kensler, Gerasimos P Sykiotis (2019) . Food and Chemical Toxicology Read on our Data CenterView on PubMed View on PMC DOI Clinical Trial
  9. Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes Annika S Axelsson, Emily Tubbs, Brig Mecham, Shaji Chacko, Hannah A Nenonen, Yunzhao Tang, Jed W Fahey, Jonathan M J Derry, Claes B Wollheim, Nils Wierup, Morey W Haymond, Stephen H Friend, Hindrik Mulder, Anders H Rosengren (2017) . Science Translational Medicine Read on our Data CenterView on PubMed DOI Clinical Trial
  10. Broccoli Sprout Extract for Glycemic Management in Patients with Chronic Kidney Disease and Type 2 Diabetes: A Randomized Double-Blind Placebo-Controlled Trial Carla Maria Avesani, Oskar Swartling, Anders H Rosengren, Olof Heimbürger, Maria K Svensson, Gregor Guron, Mårten Segelmark, Vaida Petrauskiene, Sigrid Lundberg, Andreas Jonsson, Josefin Mörtberg, Oscar Bratt, Ursa Bonnevier, Anders Fernstrom, Fredrik Uhlin, Maria Carlström, Babak Ghajavand, Anders Christensson, Roberta Fontanive Miyahira, Marie Evans, Peter Stenvinkel, INITIATE study group and the SNephR Network (2026) . Journal of Renal Nutrition Read on our Data CenterView on PubMed DOI
  11. Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China Patricia A Egner, Jian-Guo Chen, Adam T Zarth, Derek K Ng, Jin-Bing Wang, Kevin H Kensler, Lisa P Jacobson, Alvaro Muñoz, Jamie L Johnson, John D Groopman, Jed W Fahey, Paul Talalay, Jian Zhu, Tao-Yang Chen, Geng-Sun Qian, Steven G Carmella, Stephen S Hecht, Thomas W Kensler (2014) . Cancer Prevention Research Read on our Data CenterView on PubMed View on PMC DOI
  12. Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China Jian-Guo Chen, Jamie Johnson, Patricia Egner, Derek Ng, Jian Zhu, Jin-Bing Wang, Xue-Feng Xue, Yan Sun, Yong-Hui Zhang, Ling-Ling Lu, Yong-Sheng Chen, Yan Wu, Yuan-Rong Zhu, Steven Carmella, Stephen Hecht, Lisa Jacobson, Alvaro Muñoz, Kevin Kensler, Ana Rule, Jed Fahey, Thomas Kensler, John Groopman (2019) . The American Journal of Clinical Nutrition Read on our Data CenterView on PubMed View on PMC DOI
  13. Sulforaphane treatment of autism spectrum disorder (ASD) Kanwaljit Singh, Susan L Connors, Eric A Macklin, Kirby D Smith, Jed W Fahey, Paul Talalay, Andrew W Zimmerman (2014) . Proceedings of the National Academy of Sciences of the United States of America Read on our Data CenterView on PubMed View on PMC DOI
  14. Efficacy of Sulforaphane in Treatment of Children with Autism Spectrum Disorder: A Randomized Double-Blind Placebo-Controlled Multi-center Trial Jianjun Ou, Robert C Smith, Russell H Tobe, Jingjing Lin, Jen Arriaza, Jed W Fahey, Ruiting Liu, Ying Zeng, Yanan Liu, Lian Huang, Yidong Shen, Yamin Li, Daomeng Cheng, Brian Cornblatt, John M Davis, Jingping Zhao, Renrong Wu, Hua Jin (2024) . Journal of Autism and Developmental Disorders Read on our Data CenterView on PubMed DOI
  15. A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer Joshi J Alumkal, Rachel Slottke, Jacob Schwartzman, Ganesh Cherala, Myrna Munar, Julie N Graff, Tomasz M Beer, Christopher W Ryan, Dennis R Koop, Angela Gibbs, Lina Gao, Jason F Flamiatos, Erin Tucker, Richard Kleinschmidt, Motomi Mori (2015) . Investigational New Drugs Read on our Data CenterView on PubMed View on PMC DOI
  16. Transcriptional changes in prostate of men on active surveillance after a 12-mo glucoraphanin-rich broccoli intervention-results from the Effect of Sulforaphane on prostate CAncer PrEvention (ESCAPE) randomized controlled trial Maria H Traka, Antonietta Melchini, Jack Coode-Bate, Omar Al Kadhi, Shikha Saha, Marianne Defernez, Perla Troncoso-Rey, Helen Kibblewhite, Carmel M O'Neill, Federico Bernuzzi, Laura Mythen, Jackie Hughes, Paul W Needs, Jack R Dainty, George M Savva, Robert D Mills, Richard Y Ball, Colin S Cooper, Richard F Mithen (2019) . The American Journal of Clinical Nutrition Read on our Data CenterView on PubMed View on PMC DOI Clinical Trial
  17. Efficacy and Safety of Sulforaphane Added to Antipsychotics for the Treatment of Negative Symptoms of Schizophrenia: A Randomized Controlled Trial Jing Huang, AnMei Chen, Hua Jin, Fangkun Liu, Gangrui Hei, Ziwei Teng, Jingmei Xiao, Renrong Wu, Jingping Zhao, John M Davis, Ping Shao, Robert C Smith (2025) . The Journal of Clinical Psychiatry Read on our Data CenterView on PubMed DOI Clinical Trial
  18. Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled Trial Robert A Wise, Janet T Holbrook, Gerard Criner, Sanjay Sethi, Sobharani Rayapudi, Kuladeep R Sudini, Elizabeth A Sugar, Alyce Burke, Rajesh Thimmulappa, Anju Singh, Paul Talalay, Jed W Fahey, Charles S Berenson, Michael R Jacobs, Shyam Biswal, Broccoli Sprout Extract Trial Research Group (2016) . PLOS ONE Read on our Data CenterView on PubMed View on PMC DOI Clinical Trial
  19. Randomized Phase II Clinical Trial of Sulforaphane in Former Smokers at High Risk for Lung Cancer Jian-Min Yuan, Thomas W Kensler, Sanja Dacic, Douglas J Hartman, Renwei Wang, Paula A Balogh, Pamela Sufka, Melissa A Turner, Kimberly Fuhrer, Lindsey Seigh, Yen Thi-Hai Pham, Jennifer Adams-Haduch, Giuseppe Valacchi, Shivendra V Singh, James G Herman, David O Wilson (2025) . Cancer Prevention Research Read on our Data CenterView on PubMed View on PMC DOI Clinical Trial
  20. Sulforaphane Bioavailability from Glucoraphanin-Rich Broccoli: Control by Active Endogenous Myrosinase Jed W Fahey, W David Holtzclaw, Scott L Wehage, Kristina L Wade, Katherine K Stephenson, Paul Talalay (2015) . PLOS ONE Read on our Data CenterView on PubMed View on PMC DOI
  21. Bioavailability and kinetics of sulforaphane in humans after consumption of cooked versus raw broccoli Martijn Vermeulen, Ineke W A A Klöpping-Ketelaars, Robin van den Berg, Wouter H J Vaes (2008) . Journal of Agricultural and Food Chemistry Read on our Data CenterView on PubMed DOI
  22. Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design John D Clarke, Anna Hsu, Ken Riedl, Deborah Bella, Steven J Schwartz, Jan F Stevens, Emily Ho (2011) . Pharmacological Research Read on our Data CenterView on PubMed View on PMC DOI
  23. Supplementation of the Diet by Exogenous Myrosinase via Mustard Seeds to Increase the Bioavailability of Sulforaphane in Healthy Human Subjects after the Consumption of Cooked Broccoli Olukayode Okunade, Keshavan Niranjan, Sameer K Ghawi, Gunter Kuhnle, Lisa Methven (2018) . Molecular Nutrition & Food Research Read on our Data CenterView on PubMed DOI
  24. Bioavailability of Sulforaphane Following Ingestion of Glucoraphanin-Rich Broccoli Sprout and Seed Extracts with Active Myrosinase: A Pilot Study of the Effects of Proton Pump Inhibitor Administration Jed W Fahey, Kristina L Wade, Katherine K Stephenson, Anita A Panjwani, Hua Liu, Grace Cornblatt, Brian S Cornblatt, Stacy L Ownby, Edward Fuchs, Walter David Holtzclaw, Lawrence J Cheskin (2019) . Nutrients Read on our Data CenterView on PubMed View on PMC DOI
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  26. Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans Akinori Yanaka, Jed W Fahey, Atsushi Fukumoto, Mari Nakayama, Souta Inoue, Songhua Zhang, Masafumi Tauchi, Hideo Suzuki, Ichinosuke Hyodo, Masayuki Yamamoto (2009) . Cancer Prevention Research (Philadelphia) Read on our Data CenterView on PubMed DOI
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  28. A Phase 1 Randomized, Placebo-Controlled Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Enteric-Coated Stabilized Sulforaphane (SFX-01) in Male Participants Glen Clack, Christopher Moore, Linette Ruston, David Wilson, Annelize Koch, Danielle Webb, Nicholas Mallard (2025) . Advances in Therapy Read on our Data CenterView on PubMed View on PMC DOI
  29. Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder: A randomized, double-blind, placebo-controlled clinical trial Sara Momtazmanesh, Zeinab Amirimoghaddam-Yazdi, Hossein Sanjari Moghaddam, Mohammad Reza Mohammadi, Shahin Akhondzadeh (2020) . Psychiatry and Clinical Neurosciences Read on our Data CenterView on PubMed DOI
  30. Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder Andrew W Zimmerman, Kanwaljit Singh, Susan L Connors, Hua Liu, Anita A Panjwani, Li-Ching Lee, Eileen Diggins, Ann Foley, Stepan Melnyk, Indrapal N Singh, S Jill James, Richard E Frye, Jed W Fahey (2021) . Molecular Autism Read on our Data CenterView on PubMed View on PMC DOI Clinical Trial
  31. Sulforaphane Treatment in Children with Autism: A Prospective Randomized Double-Blind Study Martin Magner, Kateřina Thorová, Veronika Župová, Milan Houška, Ivana Švandová, Pavla Novotná, Jan Tříska, Naděžda Vrchotová, Ivo Soural, Ladislav Jílek (2023) . Nutrients Read on our Data CenterView on PubMed View on PMC DOI
  32. Effect of broccoli sprout extract and baseline gut microbiota on fasting blood glucose in prediabetes: a randomized, placebo-controlled trial Chinmay Dwibedi, Annika S Axelsson, Birgitta Abrahamsson, Jed W Fahey, Olof Asplund, Ola Hansson, Emma Ahlqvist, Valentina Tremaroli, Fredrik Bäckhed, Anders H Rosengren (2025) . Nature Microbiology Read on our Data CenterView on PubMed View on PMC DOI
  33. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers Julie E Bauman, Chiu-Hsieh Hsu, Sara Centuori, Jose Guillen-Rodriguez, Linda L Garland, Emily Ho, Megha Padi, Vignesh Bageerathan, Lisa Bengtson, Malgorzata Wojtowicz, Eva Szabo, H-H Sherry Chow (2022) . Cancers Read on our Data CenterView on PubMed View on PMC DOI
  34. Effects of sulforaphane on ABC and SRS scales in patients with autism spectrum disorder: a meta-analysis Jialing Guo, Yichao Wang, Weijun He, Mingxing Lou, Ying Peng, Hui Shi, Aojie Lian (2025) . Brain and Development Read on our Data CenterView on PubMed DOI
  35. Isothiocyanate concentrations and interconversion of sulforaphane to erucin in human subjects after consumption of commercial frozen broccoli compared to fresh broccoli Shikha Saha, Wendy Hollands, Birgit Teucher, Paul W Needs, Arjan Narbad, Catharine A Ortori, David A Barrett, John T Rossiter, Richard F Mithen, Paul A Kroon (2012) . Molecular Nutrition & Food Research Read on our Data CenterView on PubMed DOI
  36. The effect of sulforaphane on autism spectrum disorder: systematic review and meta-analysis Rui Wang, Zhenhui Ren, Yamin Li (2025) . EXCLI Journal Read on our Data CenterView on PubMed View on PMC DOI
  37. Dietary sulforaphane in cancer chemoprevention: epigenetic regulation and PRMT5-MEP50 complex inhibition-a systematic review Ping Yan, Changfeng Sun, Cunliang Deng (2026) . Frontiers in Pharmacology Read on our Data CenterView on PubMed View on PMC DOI
First published 15 Oct 2026 · Last verified 16 Oct 2026