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Bioavailability of Sulforaphane Following Ingestion of Glucoraphanin-Rich Broccoli Sprout and Seed Extracts with Active Myrosinase: A Pilot Study of the Effects of Proton Pump Inhibitor Administration
Nutrients
2019
11(7):1489
Bibliography
- PubMed
- PMID 31261930
- PubMed Central
- PMC6682992
- Funding
- Funded by unrestricted philanthropic donations from the Lewis B. and Dorothy Cullman Foundation and Nutramax Laboratories Consumer Care, Inc.
- Competing interests
- Most academic authors declared no financial, personal or scientific conflicts. Nutramax supplied the study supplement, and Nutramax scientists participated in blinded analysis of some biomarkers after trial completion; they did not participate in study design, execution or primary analysis.
Study snapshot
| Design | Human pharmacokinetic pilot study with paired treatment conditions |
|---|---|
| Model | Adults receiving a glucoraphanin-rich broccoli seed and sprout extract with active myrosinase |
| Sample | 16 |
| Intervention | Broccoli seed and sprout extract containing glucoraphanin and active myrosinase, tested in coated and uncoated forms and before/after omeprazole administration |
| Duration | Acute pharmacokinetic dosing across paired treatment conditions |
| Endpoints | Sulforaphane metabolite excretion; Glucoraphanin-to-sulforaphane conversion; Effect of gastric acidity; Effect of enteric coating; Peripheral blood gene expression |
What the study showed, in plain terms
Key findings
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