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Efficacy and Safety of Sulforaphane Added to Antipsychotics for the Treatment of Negative Symptoms of Schizophrenia: A Randomized Controlled Trial
The Journal of Clinical Psychiatry
2025
86(1):24m15272
Bibliography
- PubMed
- PMID 39832347
- Trial registry
- View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
- Funding
- Supported by the Natural Science Foundation of Hunan (2022JJ40691) and the Science and Technology Innovation Program of Hunan Province (2024RC3055). The products were procured by the research team from Nutramax through a Chinese company; Nutramax had no role in study design or interpretation.
- Competing interests
- The authors reported no financial or other relationship relevant to the article.
Study snapshot
| Design | Randomized double-blind placebo-controlled add-on clinical trial |
|---|---|
| Model | Antipsychotic-treated adults with schizophrenia |
| Sample | 77 participants with at least one postintervention assessment (53 sulforaphane, 24 placebo) |
| Intervention | Antipsychotics plus 1,700 mg/day Avmacol Extra Strength versus antipsychotics plus placebo. |
| Duration | 24 weeks |
| Endpoints | PANSS negative symptom total score; PANSS negative factor score; Depression factors; Cognitive factors; Safety |
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Key findings
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