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Sulforaphane Bioavailability from Glucoraphanin-Rich Broccoli: Control by Active Endogenous Myrosinase
PLOS ONE
2015
10(11):e0140963
Bibliography
- PubMed
- PMID 26524341
- PubMed Central
- PMC4629881
- Funding
- Supported by an unrestricted donation from the Lewis B. and Dorothy Cullman Foundation. Brassica Protection Products LLC funded inclusion of a commercial supplement, and Xymogen supplied the supplements. The paper states that funders had no role in study design, data collection or analysis, publication decision, or manuscript preparation.
- Competing interests
- The authors declared no competing interests.
Study snapshot
| Design | Human pharmacokinetic and bioavailability study across several broccoli-derived preparations |
|---|---|
| Model | Human volunteers receiving glucoraphanin- or sulforaphane-delivery preparations |
| Sample | Multiple small human cohorts; cohort sizes varied by preparation |
| Intervention | Glucoraphanin-rich broccoli sprout or seed preparations delivered with or without active endogenous myrosinase, including commercial and investigator-prepared supplements. |
| Duration | |
| Endpoints | Urinary sulforaphane metabolite recovery; Glucoraphanin-to-sulforaphane conversion; Bioavailability; Interindividual variability |
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