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Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial
Food and Chemical Toxicology
2019
126:1-6
Bibliography
- PubMed
- PMID 30735751
- PubMed Central
- PMC6422739
- Trial registry
- View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
- Funding
- The parent clinical trial was funded by NIH P01 ES006052. The thyroid analysis also reported support from COST Action CA16112 NutRedOx, NIH R35 CA197222, and Marie Curie PIOF-GA-2012-329442 ADIPONRF2.
Study snapshot
| Design | Randomized clinical trial safety analysis |
|---|---|
| Model | Adult women consuming a sulforaphane- and glucoraphanin-enriched broccoli sprout beverage |
| Sample | 45 female participants |
| Intervention | Daily broccoli sprout beverage providing 40 μmol sulforaphane plus 600 μmol glucoraphanin for 84 consecutive days versus placebo; the thyroid analysis used serum samples from 45 female participants in the parent randomized trial. |
| Duration | 12 weeks (84 days) |
| Endpoints | TSH; Free thyroxine (fT4); Thyroglobulin; Thyroid autoimmunity status |
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