Tier 1 — highest
Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract
Molecular Nutrition & Food Research
2015
59(3):424-433
Bibliography
- PubMed
- PMID 25522265
- PubMed Central
- PMC4394840
- Funding
- NIH grants P01 CA090890, R01 CA122906 and P30 ES000210.
- Competing interests
- The authors declared no conflict of interest.
Study snapshot
| Design | Randomized human feeding study comparing delivery form and dosing schedule |
|---|---|
| Model | Healthy adults |
| Sample | 10 participants |
| Intervention | Fresh broccoli sprouts or myrosinase-treated broccoli sprout extract providing 200 µmol sulforaphane equivalents daily, given either once or as two 100-µmol doses 12 hours apart. |
| Duration | |
| Endpoints | Plasma sulforaphane metabolites; Urinary sulforaphane metabolites; Absorption; Exposure over time; HO-1; HDAC activity; p21 |
What the study showed, in plain terms
Key findings
What this study can and cannot tell us
Citation network
Articles citing this research paper
Biohack Blueprint analyses that reference this study in their evidence base.
- Best Sulforaphane Supplements 2026: What Actually Delivers Sulforaphane?The best sulforaphane supplements of 2026 ranked by active myrosinase, glucoraphanin transparency, delivery design, human evidence, quality controls and value—not broccoli-extract milligrams.Read analysis
- Broccoli Sprouts vs Sulforaphane Supplements: Human Absorption ComparedBroccoli sprouts vs sulforaphane supplements using human absorption data: fresh sprouts, myrosinase, standardized supplements, dose variability, convenience and who each option fits.Read analysis
- Foods High in Sulforaphane: Broccoli Sprouts, Cooking & MyrosinaseFoods high in sulforaphane explained by human evidence: broccoli sprouts, raw vs cooked broccoli, mustard-seed myrosinase, cruciferous vegetables and preparation.Read analysis
- Sulforaphane Dosage: Human Trial Doses, µmol to mg & MyrosinaseSulforaphane dosage explained without label confusion: human trial doses, µmol-to-mg conversion, glucoraphanin vs sulforaphane, myrosinase, bioavailability and safety.Read analysis
- Sulforaphane Benefits: Human Evidence Ranked by Strength (2026)Sulforaphane benefits ranked by human evidence across 37 papers: bioavailability, pollutant biomarkers, blood sugar, autism, NRF2, H. pylori, cancer and key limitations.Read analysis
- Sulforaphane Supplement Guide: Forms, Myrosinase & Human EvidenceThe evidence-led sulforaphane supplement pillar: forms, active myrosinase, delivered dose, bioavailability, benefits, dosage, safety, foods and the complete 37-paper evidence architecture.Read analysis
Editorial review
Reviewed by the Biohack Blueprint research team
Last verified
