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Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China

Jian-Guo Chen, Jamie Johnson, Patricia Egner, Derek Ng, Jian Zhu, Jin-Bing Wang, Xue-Feng Xue, Yan Sun, Yong-Hui Zhang, Ling-Ling Lu, Yong-Sheng Chen, Yan Wu, Yuan-Rong Zhu, Steven Carmella, Stephen Hecht, Lisa Jacobson, Alvaro Muñoz, Kevin Kensler, Ana Rule, Jed Fahey, Thomas Kensler, John Groopman
The American Journal of Clinical Nutrition 2019 110(3):675-684

Bibliography

PubMed
PMID 31268126
PubMed Central
PMC6736426
Funding
Supported in part by NIH grants R01 CA190610 and R35 CA197222.
Competing interests
The authors reported no conflicts of interest.

Study snapshot

DesignRandomized placebo-controlled multidose clinical trial
ModelAdults in Qidong, China exposed to ambient benzene and other air pollutants
Sample170 participants
InterventionPlacebo or one of three graded concentrations of broccoli sprout beverage (full, one-half or one-fifth dose) for 10 consecutive days.
Duration10 days
EndpointsUrinary S-phenylmercapturic acid (SPMA); Benzene detoxication biomarker; Dose-response relationship

What the study showed, in plain terms

This randomized multidose trial followed earlier Qidong research by asking how much broccoli sprout beverage was required to measurably increase urinary excretion of a benzene detoxication biomarker.

Key findings

The full-dose broccoli sprout beverage significantly increased urinary SPMA, while the lower tested concentrations did not produce statistically significant increases. The study therefore demonstrated a dose-dependent biomarker response rather than a uniform effect at any dose.

What this study can and cannot tell us

The intervention lasted only 10 days and the endpoint was a urinary benzene-metabolism biomarker, not a clinical health outcome. The results should not be used to claim disease prevention from air pollution.

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