Tier 1 — highest
Transcriptional changes in prostate of men on active surveillance after a 12-mo glucoraphanin-rich broccoli intervention-results from the Effect of Sulforaphane on prostate CAncer PrEvention (ESCAPE) randomized controlled trial
The American Journal of Clinical Nutrition
2019
109(4):1133-1144
Bibliography
- PubMed
- PMID 30982861
- PubMed Central
- PMC6462431
- Trial registry
- View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
- Funding
- Supported by the Prostate Cancer Foundation Challenge Award 2012 and UK Biotechnology and Biological Sciences Research Council grant BB/J004545/1. The paper states that funders had no role in study design, conduct, analysis, interpretation, or manuscript preparation.
- Competing interests
- Richard F. Mithen was an inventor on a patent for broccoli with elevated glucoraphanin; Mithen, Maria H. Traka and Antonietta Melchini were co-inventors on two patents covering glucoraphanin/SMCSO combinations for prostate cancer. No other study-related conflicts were reported.
Study snapshot
| Design | Three-arm parallel randomized double-blinded dietary intervention |
|---|---|
| Model | Men with localized prostate cancer on active surveillance |
| Sample | 49 participants completed |
| Intervention | Weekly 300 mL soup made from standard broccoli or experimental broccoli delivering approximately 3-fold or 7-fold higher glucoraphanin. |
| Duration | 12 months |
| Endpoints | Prostate tissue gene expression; Oncogenic pathway expression; RNA sequencing; Dietary exposure; Clinical progression exploratory observations |
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