Betaine modulates age-related NF-kappaB by thiol-enhancing action
Experimental animal and/or laboratory research. Betaine modified thiol status and reduced selected NF-kappaB-related inflammatory signals in the experimental systems.
TMG Research Library — Records 381–415
Records 381–415 of 415. Open a study to inspect the full evidence record. Source links lead directly to the publication. Updated 19 October 2026.
Preclinical aging, brain and metabolic mechanisms (35)
Preclinical aging, brain and metabolic mechanisms
Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis
Experimental animal and/or laboratory research. Betaine attenuated liver-fat accumulation alongside increased AMPK activation and reduced lipogenic activity.
Rectification of impaired adipose tissue methylation status and lipolytic response contributes to hepatoprotective effect of betaine in a mouse model of alcoholic liver disease
Experimental animal and/or laboratory research. Betaine improved selected liver and adipose-tissue changes, including methylation-associated regulation of lipolysis.
Betaine, a component of Lycium chinense, enhances muscular endurance of mice and myogenesis of myoblasts
Experimental animal and/or laboratory research. Lycium-containing food improved mouse endurance, while extract and betaine promoted selected myogenesis measures in cells.
Betaine ameliorates schizophrenic traits by functionally compensating for KIF3-based CRMP2 transport
Experimental animal and/or laboratory research. Betaine improved selected schizophrenia-like mouse behaviors and neuronal morphology, with a proposed CRMP2-transport mechanism.
The BHMT-betaine methylation pathway epigenetically modulates oligodendrocyte maturation
Experimental animal and/or laboratory research. Betaine changed methyltransferase activity and maturation-related genes in oligodendrocyte models, dependent on BHMT expression.
Betaine Mitigates Amyloid-β-Associated Neuroinflammation by Suppressing the NLRP3 and NF-κB Signaling Pathways in Microglial Cells
Experimental animal and/or laboratory research. Betaine reduced selected cytokines and NLRP3/NF-kappaB activation without reducing cell viability in the tested model.
Betaine prevents cognitive dysfunction by suppressing hippocampal microglial activation in chronic social isolated male mice
Experimental animal and/or laboratory research. Cognitive behavior and microglial measures improved, but depression-like behavior did not clearly improve.
Betaine suppressed Aβ generation by altering amyloid precursor protein processing
Experimental animal and/or laboratory research. Betaine reduced measured amyloid-beta production and shifted secretase-related APP processing in the cell model.
Prophylactic Effects of Betaine on Depression and Anxiety Behaviors in Mice with Dextran Sulfate Sodium-Induced Colitis
Experimental animal and/or laboratory research. Betaine improved colonic and selected anxiety/depression-like measures, with proposed mitochondrial and cGAS-STING mechanisms.
Betaine Attenuates Hyperhomocysteinemia-Induced Cognitive Impairment by Suppressing Oxidative Stress and Activating the PI3K/AKT/GSK-3β Pathway
Experimental animal and/or laboratory research. Betaine improved selected cognitive and oxidative-stress measures, with experiments implicating PI3K/AKT/GSK-3beta signaling.
Betaine alleviates fluoride-induced learning and memory impairment in offspring rats through DNA methylation of GNAS
Experimental animal and/or laboratory research. Selected learning, hippocampal and GNAS-methylation changes favored betaine in the fluoride-exposed rat model.
Betaine-driven Keap1 methylation promotes p62-mediated autophagy and Nrf2 stabilization to alleviate glutathione-dependent redox dyshomeostasis in liver injury
Experimental animal and/or laboratory research. The study linked betaine exposure to Keap1 modification, autophagy, Nrf2 stabilization and improved redox measures in experimental liver injury.
Betaine alleviates neuronal impairment in glutamate-injured SH-SY5Y neuroblastoma cells via Nrf2 signaling pathway related ferroptosis
Experimental animal and/or laboratory research. Betaine improved viability and selected ferroptosis/oxidative-stress markers, alongside Nrf2-related changes.
Betaine postpones hyperglycemia-related senescence in ovarian and testicular cells: Involvement of RAGE and β-galactosidase
Experimental animal and/or laboratory research. Betaine reduced selected oxidative and senescence-associated markers in high-glucose cell cultures.
Identifying Aberrant 1CM-Related Pathways by Multi-Omics Analysis and Validating Tumor Inhibitory Effect of One-Carbon Donor Betaine in Gastric Cancer
Experimental animal and/or laboratory research. Human profiling identified one-carbon pathway differences; betaine inhibited selected malignant cell behaviors in laboratory tests.
Betaine inhibits the stem cell-like properties of hepatocellular carcinoma by activating autophagy via SAM/m6A/YTHDF1-mediated enhancement on ATG3 stability
Experimental animal and/or laboratory research. Betaine reduced selected stem-like tumor properties in models through a proposed SAM/m6A/YTHDF1/ATG3-autophagy pathway.
Betaine induces ferroptotic stress by enhancing KEAP1-mediated NRF2 degradation in breast cancer cells
Experimental animal and/or laboratory research. Betaine increased ferroptosis-associated stress and reduced selected malignant cell behaviors, involving KEAP1/NRF2 regulation.
Betaine promotes cell differentiation of human osteoblasts in primary culture
Experimental animal and/or laboratory research. Betaine increased selected osteogenic genes and calcium, ERK and IGF-related signaling in cultured bone cells.
Betaine stabilizes cell volume and protects against apoptosis in human corneal epithelial cells under hyperosmotic stress
Experimental animal and/or laboratory research. Betaine reduced cell shrinkage and apoptosis in the laboratory hyperosmotic-stress model.
Betaine reduces the expression of inflammatory adipokines caused by hypoxia in human adipocytes
Experimental animal and/or laboratory research. Selected hypoxia-induced inflammatory gene-expression changes were attenuated by betaine.
Effects of L-carnitine, erythritol and betaine on pro-inflammatory markers in primary human corneal epithelial cells exposed to hyperosmotic stress
Experimental animal and/or laboratory research. The osmoprotectants suppressed selected inflammatory responses under hyperosmotic stress, with differing effects among compounds.
Betaine Ameliorates Acute Sever Ulcerative Colitis by Inhibiting Oxidative Stress Induced Inflammatory Pyroptosis
Experimental animal and/or laboratory research. Betaine reduced selected disease-activity, barrier-injury and inflammatory-pyroptosis measures.
The Alleviating Effects and Mechanisms of Betaine on Dextran Sulfate Sodium-Induced Colitis in Mice
Experimental animal and/or laboratory research. Betaine improved selected barrier measures and inhibited NF-kappaB/MLCK-related signaling in the models.
A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment
Experimental animal and/or laboratory research. The model reproduced severe metabolic abnormalities and hypercoagulation; betaine improved the coagulation phenotype.
Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk
Experimental animal and/or laboratory research. Homocysteine-lowering efficacy diminished over time and inflammatory/coagulation abnormalities returned as homocysteine rose.
Taurine alleviates repression of betaine-homocysteine S-methyltransferase and significantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine β-synthase-deficient homocystinuria
Experimental animal and/or laboratory research. Taurine restored BHMT-related responses and enhanced betaine-associated homocysteine lowering in the mouse model.
Betaine Treatment Prevents TNF-α-Mediated Muscle Atrophy by Restoring Total Protein Synthesis Rate and Morphology in Cultured Myotubes
Experimental animal and/or laboratory research. Betaine attenuated TNF-alpha-associated reductions in protein synthesis and adverse myotube morphology.
Betaine supplementation alleviates dextran sulfate sodium-induced colitis via regulating the inflammatory response, enhancing the intestinal barrier, and altering gut microbiota
Experimental animal and/or laboratory research. Betaine improved selected inflammatory and barrier measures and altered the microbiome in the mouse model.
Maternal Choline and Betaine Supplementation Modifies the Placental Response to Hyperglycemia in Mice and Human Trophoblasts
Experimental animal and/or laboratory research. Betaine modified some placental morphology and glucose-transport measures under experimental hyperglycemia.
Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice
Experimental animal and/or laboratory research. Mouse glucose and liver-fat outcomes improved in an FGF21-dependent manner; lower human betaine was associated with insulin resistance.
Dietary betaine prevents obesity through gut microbiota-drived microRNA-378a family
Experimental animal and/or laboratory research. Betaine-associated metabolic effects depended partly on microbiota and were linked to a proposed microRNA-378a/YY1 pathway.
Betaine for the prevention and treatment of insulin resistance and fatty liver in a high-fat dietary model of insulin resistance in C57BL mice
Experimental animal and/or laboratory research. Betaine improved selected glucose, liver-injury and insulin-signaling measures in the experimental systems.
Unveiling the crucial role of betaine: modulation of GABA homeostasis via SLC6A1 transporter (GAT1)
Experimental animal and/or laboratory research. Betaine acted as a context-dependent GAT1 modulator, with concentration-related effects on GABA transport.
A new perspective on betaine: Targeting the glycine binding site of the NMDA receptor
Experimental animal and/or laboratory research. Betaine modified NMDA-receptor activity in opposite directions depending on receptor and co-ligand context.
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