Tier 3 — preclinical

Betaine reduces the expression of inflammatory adipokines caused by hypoxia in human adipocytes

K Olli, S Lahtinen, N Rautonen, K Tiihonen
The British journal of nutrition 2013 109(1):43-49

Bibliography

PubMed
PMID 22424556
DOI
10.1017/S0007114512000888
Funding
Funding was not specified in the indexed record or accessible funding metadata.
Competing interests
A competing-interest declaration was not available in the indexed record or accessible disclosure metadata.

Study snapshot

DesignExperimental animal and/or laboratory research
ModelCultured human adipocytes
SampleExperiment-specific biological replicates and model groups; see original methods
InterventionBetaine 250 micromol/L during low-oxygen exposure
Duration8-20 hours
EndpointsAdipokines; Hypoxia; Inflammation

What the study showed, in plain terms

Published in 2013, this source examined preclinical aging, brain and metabolic mechanisms. Design: Experimental animal and/or laboratory research. Sample/model: Experiment-specific biological replicates and model groups; see original methods. The exposure or intervention was Betaine 250 micromol/L during low-oxygen exposure. Follow-up or treatment period: 8-20 hours.

Selected hypoxia-induced inflammatory gene-expression changes were attenuated by betaine.

Experimental model evidence. The intervention, concentrations and outcomes do not establish an effective human supplement dose or a clinical treatment benefit.

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Key findings

  • Selected hypoxia-induced inflammatory gene-expression changes were attenuated by betaine.
  • The recorded outcome domains were Adipokines; Hypoxia; Inflammation.
  • The result applies to the tested exposure: Betaine 250 micromol/L during low-oxygen exposure; 8-20 hours.

What this study can and cannot tell us

  • Experimental model evidence. The intervention, concentrations and outcomes do not establish an effective human supplement dose or a clinical treatment benefit.
  • Cell concentrations, species, disease models and experimental routes cannot be converted directly into an effective or safe oral human regimen.
  • Source basis: Indexed abstract and bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology