Tier 3 — preclinical

Taurine alleviates repression of betaine-homocysteine S-methyltransferase and significantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine β-synthase-deficient homocystinuria

Kenneth N Maclean, Hua Jiang, Whitney N Phinney, Amy K Keating, K Joseph Hurt, Sally P Stabler
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 33(5):6339-6353

Bibliography

PubMed
PMID 30768359
DOI
10.1096/fj.201802069RR
Funding
Funding was not specified in the indexed record or accessible funding metadata.
Competing interests
A competing-interest declaration was not available in the indexed record or accessible disclosure metadata.

Study snapshot

DesignExperimental animal and/or laboratory research
ModelCBS-deficient mice
SampleExperiment-specific biological replicates and model groups; see original methods
InterventionTaurine added to long-term betaine treatment
DurationLong-term model experiments
EndpointsBHMT; Taurine combination; Homocysteine

What the study showed, in plain terms

Published in 2019, this source examined preclinical aging, brain and metabolic mechanisms. Design: Experimental animal and/or laboratory research. Sample/model: Experiment-specific biological replicates and model groups; see original methods. The exposure or intervention was Taurine added to long-term betaine treatment. Follow-up or treatment period: Long-term model experiments.

Taurine restored BHMT-related responses and enhanced betaine-associated homocysteine lowering in the mouse model.

Experimental model evidence. The intervention, concentrations and outcomes do not establish an effective human supplement dose or a clinical treatment benefit.

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Key findings

  • Taurine restored BHMT-related responses and enhanced betaine-associated homocysteine lowering in the mouse model.
  • The recorded outcome domains were BHMT; Taurine combination; Homocysteine.
  • The result applies to the tested exposure: Taurine added to long-term betaine treatment; Long-term model experiments.

What this study can and cannot tell us

  • Experimental model evidence. The intervention, concentrations and outcomes do not establish an effective human supplement dose or a clinical treatment benefit.
  • Cell concentrations, species, disease models and experimental routes cannot be converted directly into an effective or safe oral human regimen.
  • Source basis: Indexed abstract and bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology