Tier 3 — preclinical

Betaine modulates age-related NF-kappaB by thiol-enhancing action

Eun Kyung Go, Kyung Jin Jung, Ji Min Kim, Hyunae Lim, Hyeang Kwan Lim, Byung Pal Yu, Hae Young Chung
Biological & pharmaceutical bulletin 2007 30(12):2244-2249

Bibliography

PubMed
PMID 18057706
DOI
10.1248/bpb.30.2244
Funding
Funding was not specified in the indexed record or accessible funding metadata.
Competing interests
A competing-interest declaration was not available in the indexed record or accessible disclosure metadata.

Study snapshot

DesignExperimental animal and/or laboratory research
ModelAged rats and HEK293T cells
SampleExperiment-specific biological replicates and model groups; see original methods
InterventionDietary betaine and glutathione-depletion cell challenges
Duration10-day rat feeding experiment
EndpointsThiol status; NF-kappaB; Aging mechanisms

What the study showed, in plain terms

Published in 2007, this source examined preclinical aging, brain and metabolic mechanisms. Design: Experimental animal and/or laboratory research. Sample/model: Experiment-specific biological replicates and model groups; see original methods. The exposure or intervention was Dietary betaine and glutathione-depletion cell challenges. Follow-up or treatment period: 10-day rat feeding experiment.

Betaine modified thiol status and reduced selected NF-kappaB-related inflammatory signals in the experimental systems.

Experimental model evidence. The intervention, concentrations and outcomes do not establish an effective human supplement dose or a clinical treatment benefit.

Continue with TMG Data Center

Continue with TMG Supplement: Trimethylglycine Benefits, Uses and Evidence

Key findings

  • Betaine modified thiol status and reduced selected NF-kappaB-related inflammatory signals in the experimental systems.
  • The recorded outcome domains were Thiol status; NF-kappaB; Aging mechanisms.
  • The result applies to the tested exposure: Dietary betaine and glutathione-depletion cell challenges; 10-day rat feeding experiment.

What this study can and cannot tell us

  • Experimental model evidence. The intervention, concentrations and outcomes do not establish an effective human supplement dose or a clinical treatment benefit.
  • Cell concentrations, species, disease models and experimental routes cannot be converted directly into an effective or safe oral human regimen.
  • Source basis: Indexed abstract and bibliographic data. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

Tier 3
Systematic profiling reveals betaine as an exercise mimetic for geroprotection
Lingling Geng et al. · Cell · 2025
Tier 4
Betaine and aging: A narrative review of findings, possible mechanisms, research perspectives, and practical recommendations
Emilia Zawieja et al. · Ageing research reviews · 2025
Tier 4
Beneficial Effects of Betaine: A Comprehensive Review
Madan Kumar Arumugam et al. · Biology · 2021
Tier 4
Decoding Betaine: A Critical Analysis of Therapeutic Potential Compared with Marketing Hype-A Narrative Review
Grzegorz Nikrandt et al. · The Journal of nutrition · 2024

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology