Tier 3 — preclinical

The Alleviating Effects and Mechanisms of Betaine on Dextran Sulfate Sodium-Induced Colitis in Mice

Weidong Dou, Hao Xu, Shuo Feng, Tao Liu, Lin Xiao, Yingchao Wu, Shanwen Chen, Yisheng Pan, Xin Wang
Molecular nutrition & food research 2023 67(24):e2300376

Bibliography

PubMed
PMID 37815169
DOI
10.1002/mnfr.202300376
Funding
Funding was not specified in the indexed record or accessible funding metadata.
Competing interests
A competing-interest declaration was not available in the indexed record or accessible disclosure metadata.

Study snapshot

DesignExperimental animal and/or laboratory research
ModelDSS-treated mice and Caco-2 monolayers
SampleExperiment-specific biological replicates and model groups; see original methods
InterventionExperimental betaine exposure
DurationModel-specific mouse and cell protocols
EndpointsIntestinal barrier; NF-kappaB; MLCK

What the study showed, in plain terms

Published in 2023, this source examined preclinical aging, brain and metabolic mechanisms. Design: Experimental animal and/or laboratory research. Sample/model: Experiment-specific biological replicates and model groups; see original methods. The exposure or intervention was Experimental betaine exposure. Follow-up or treatment period: Model-specific mouse and cell protocols.

Betaine improved selected barrier measures and inhibited NF-kappaB/MLCK-related signaling in the models.

Experimental model evidence. The intervention, concentrations and outcomes do not establish an effective human supplement dose or a clinical treatment benefit.

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Key findings

  • Betaine improved selected barrier measures and inhibited NF-kappaB/MLCK-related signaling in the models.
  • The recorded outcome domains were Intestinal barrier; NF-kappaB; MLCK.
  • The result applies to the tested exposure: Experimental betaine exposure; Model-specific mouse and cell protocols.

What this study can and cannot tell us

  • Experimental model evidence. The intervention, concentrations and outcomes do not establish an effective human supplement dose or a clinical treatment benefit.
  • Cell concentrations, species, disease models and experimental routes cannot be converted directly into an effective or safe oral human regimen.
  • Source basis: Indexed abstract and bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology