Exercise-mimicking effects of betaine in chronic disease prevention and management
Narrative review. Discusses betaine as a potential exercise-mimetic candidate for chronic-disease research.
TMG Research Library — Records 221–260
Records 221–260 of 415. Open a study to inspect the full evidence record. Source links lead directly to the publication. Updated 19 October 2026.
Mechanistic and clinical reviews (25) · Historical reports and formulation context (11) · Human observational and biomarker research (4)
Mechanistic and clinical reviews
Betaine, metabolic by-product or vital methylating agent?
Narrative review. Presents an early hypothesis that betaine serves as a functional methyl donor when other pathways are impaired.
The anti-diabetic potential of betaine. Mechanisms of action in rodent models of type 2 diabetes
Narrative review. Reviews glucose, insulin-signaling and stress-response effects reported in rodent diabetes models.
Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium
Narrative review. Summarizes a symposium on SAMe, folate and betaine mechanisms in alcohol-associated liver injury.
Betaine transport in kidney and liver: use of betaine in liver injury
Narrative review. Reviews betaine transport in kidney and liver and its possible relevance to liver injury.
Fibrates plus betaine: a winning combination?
Narrative review. Proposes testing betaine alongside fibrates because some fibrates increase urinary betaine loss.
Original sources: PubMed
Effects of betaine intake on plasma homocysteine concentrations and consequences for health
Narrative review. Reviews dose-related homocysteine lowering and the possibility that lipid increases could offset proposed vascular benefits.
Betaine: A Promising Natural Product for Neurological and Psychiatric Diseases
Narrative review. Surveys neurological and psychiatric hypotheses involving methylation, inflammation and neurotransmission.
Urea, TMAO, betaine and other osmolytes as endogenous diuretics in heart failure and hypertension
Narrative review. Discusses endogenous osmolytes as possible contributors to diuresis and fluid regulation.
Therapeutic potential of betaine and its derivatives in cancer treatment: a comprehensive review
Narrative review. Reviews betaine and chemically modified derivatives in experimental cancer research.
Osmotic regulation of renal betaine transport: transcription and beyond
Narrative review. Reviews transcriptional and protein-trafficking control of renal betaine transport under osmotic stress.
The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway
Narrative review. Explains the metabolic consequences of methyl-donor shortage and BHMT-linked remethylation.
Effects of betaine on performance and body composition: a review of recent findings and potential mechanisms
Narrative review. Reviews early performance and body-composition findings and possible metabolic mechanisms.
Betaine homocysteine S-methyltransferase: just a regulator of homocysteine metabolism?
Narrative review. Reviews BHMT structure, enzymatic function and possible roles beyond homocysteine regulation.
The glycine betaine role in neurodegenerative, cardiovascular, hepatic, and renal diseases: Insights into disease and dysfunction networks
Narrative review. Integrates proposed betaine pathways across brain, cardiovascular, liver and kidney disorders.
Preservation and modulation of peritoneal function. A potential role of pyruvate and betaine
Narrative review. Discusses osmolytes including betaine as possible ways to protect the peritoneal membrane during dialysis.
Glycine betaine rather than acting only as an osmolyte also plays a role as regulator in cellular metabolism
Narrative review. Reviews betaine as a metabolic regulator and protein stabilizer in addition to an osmolyte.
Alleviation of dietary cirrhosis by betaine and other lipotropic agents
Historical review; abstract unavailable. The indexed record verifies the publication and citation, but supplies no abstract. A quantitative effect or complete treatment result is not established from this record alone.
Making the case for prophylactic use of betaine to promote brain health in young (15-24 year old) athletes at risk for concussion
Narrative review. Proposes preventive betaine use in young athletes based on brain-protection hypotheses.
Skeletal muscle mitochondrial-methylation-neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
Narrative review. Proposes a combined model involving betaine, tyrosine and Cordyceps for exercise adaptation.
Nonalcoholic fatty liver disease: relationship to insulin sensitivity and oxidative stress. Treatment approaches using vitamin E, magnesium, and betaine
Narrative review. Reviews early approaches to fatty liver involving vitamin E, magnesium and betaine.
Original sources: PubMed
Betaine in Metabolic Dysfunction-Associated Steatotic Liver Disease: Mechanisms of Action and Therapeutic Potential
Narrative review. Reviews recent MASLD mechanisms and concludes that clinical therapeutic efficacy remains unestablished.
Dietary choline and betaine intakes and risk of cardiovascular diseases: review of epidemiological evidence
Narrative review. Reviews dietary choline/betaine studies and metabolic risk associations available through 2009.
Betaine supplementation and blood lipids: fact or artifact?
Narrative review. Discusses whether betaine-associated LDL changes could counterbalance homocysteine lowering.
Betaine supplementation and the metabolic syndrome
Indexed letter or commentary; abstract unavailable. The indexed record verifies the publication and citation, but supplies no abstract. A quantitative effect or complete treatment result is not established from this record alone.
Historical reports and formulation context
[Treatment of liver diseases, especially of fatty liver with betaine citrate]
Indexed clinical report; abstract unavailable. The indexed record verifies the publication and citation, but supplies no abstract. A quantitative effect or complete treatment result is not established from this record alone.
Original sources: PubMed
[Significance of combined arginine-betaine-sorbitol therapy in the treatment of metabolic liver diseases]
Indexed case report; abstract unavailable. The indexed record verifies the publication and citation, but supplies no abstract. A quantitative effect or complete treatment result is not established from this record alone.
Original sources: PubMed
[STATISTICAL METHODS FOR ESTIMATING THE THERAPEUTIC VALUE OF A DRUG. APPLICATION TO THE TREATMENT OF NON-ORGANIC DYSPEPTIC DISORDERS WITH A COMBINATION OF ASCORBATE AND BETAINE HYDRATE]
Indexed clinical report; abstract unavailable. The indexed record verifies the publication and citation, but supplies no abstract. A quantitative effect or complete treatment result is not established from this record alone.
Original sources: PubMed
[Treatment of human atherosclerosis with betaine]
Indexed clinical report; abstract unavailable. The indexed record verifies the publication and citation, but supplies no abstract. A quantitative effect or complete treatment result is not established from this record alone.
Original sources: PubMed
[Place of betaine citrate in the treatment of psoriasis]
Indexed clinical report; abstract unavailable. The indexed record verifies the publication and citation, but supplies no abstract. A quantitative effect or complete treatment result is not established from this record alone.
Original sources: PubMed
Glycocyamine betaine as an adjunct in the treatment of neuromuscular disease patients
Indexed clinical report; abstract unavailable. The indexed record verifies the publication and citation, but supplies no abstract. A quantitative effect or complete treatment result is not established from this record alone.
Original sources: PubMed
Betaine and glycocyamine in treatment of poliomyelitis
Indexed clinical report; abstract unavailable. The indexed record verifies the publication and citation, but supplies no abstract. A quantitative effect or complete treatment result is not established from this record alone.
Results of betaine treatment of atherosclerosis
Indexed clinical report; abstract unavailable. The indexed record verifies the publication and citation, but supplies no abstract. A quantitative effect or complete treatment result is not established from this record alone.
Betaine and glycocyamine in the treatment of disability resulting from acute anterior poliomyelitis
Indexed clinical report; abstract unavailable. The indexed record verifies the publication and citation, but supplies no abstract. A quantitative effect or complete treatment result is not established from this record alone.
Original sources: PubMed
Use of betaine and glycocyamine in the treatment of patients with heart disease: preliminary report
Indexed clinical report; abstract unavailable. The indexed record verifies the publication and citation, but supplies no abstract. A quantitative effect or complete treatment result is not established from this record alone.
Original sources: PubMed
Treatment of cardiac decompensation with betaine and glycocyamine
Indexed clinical report; abstract unavailable. The indexed record verifies the publication and citation, but supplies no abstract. A quantitative effect or complete treatment result is not established from this record alone.
Original sources: PubMed
Human observational and biomarker research
Urinary betaine/creatinine ratio enhances diagnostic accuracy of PLA2R-Ab in idiopathic membranous nephropathy
Diagnostic biomarker study. Urinary betaine/creatinine improved discrimination when combined with PLA2R antibodies, but broader clinical validation remained necessary.
Association between plasma betaine levels and dysglycemia in patients with coronary artery disease
Case-control biomarker study. Betaine was lower in coronary-disease patients with dysglycemia and inversely associated with several glycemic and metabolic measures.
Dietary Choline and Betaine Intake and Risk of Colorectal Cancer in an Iranian Population
Case-control study. Higher estimated betaine intake was associated with modestly lower colorectal-cancer odds, while some choline forms showed opposite associations.
Association Between Dietary Betaine Intake and Dyslipidemia in Chinese Children and Adolescents: A Cross-Sectional Study
Cross-sectional study. Higher dietary betaine, particularly from plant foods, was associated with lower odds of selected lipid abnormalities.
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