Product Review

DoNotAge Pure Vitamin D3, K2 & Magnesium Review

5/5 Editorial scoreRECOMMENDED

Our 5/5 three-in-one pick for adults whose vitamin D plan calls for this strength. One daily capsule combines 5,000 IU D3, 120 micrograms MK-7 and 250 mg magnesium L-threonate. The...

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By Dr. Khaled Mahmoud, MBBCh

Reviewed by Dr. Amr Yasser, PhD, Dr. Abdulla Mostafa, PhD

· 16 min read

How we scored it

Our editorial recommendation uses a 1–5 scale. We consider the formulation, label clarity, manufacturer quality disclosures, practical use and value for the intended reader. The published rating is an overall editorial judgment; these factors are not separately measured or weighted.

5/5 means a top editorial recommendation for the stated use case. It does not establish clinical effectiveness or mean that we performed laboratory testing. Research strength and safety limitations are assessed separately in this review.

5/5 editorial rating for formula, convenience and value when 5,000 IU D3 suits your plan. Based on label and research review; not a customer average or hands-on trial.

Read the review summary

A detailed review of DoNotAge’s one-capsule D3, MK-7 and magnesium L-threonate combination: label amounts, value, use and human research.

Our 5/5 three-in-one pick for adults whose vitamin D plan calls for this strength. One daily capsule combines 5,000 IU D3, 120 micrograms MK-7 and 250 mg magnesium L-threonate. The reason to choose it is convenience, useful forms and annual-pack value. Check the D3 strength and remember that L-threonate compound weight is different from elemental magnesium.

Evidence for an ingredient does not establish the effects of this finished product. See the evidence section for study design, dose and limitations.

DoNotAge Pure Vitamin D3, K2 and Magnesium 366-capsule bottle. View image

DoNotAge Pure Vitamin D3, K2 and Magnesium 366-capsule bottle.

Read the full editorial assessment

DoNotAge Pure Vitamin D3, K2 & Magnesium is our #1 three-in-one choice for adults who want D3, MK-7 and magnesium L-threonate in a simple daily capsule, when its 5,000 IU D3 strength fits their plan. We rate it 5/5 for the combination of useful ingredient forms, a low-effort routine, sensible pack choices and strong annual-pack value.

The most appealing feature is how easy it makes a coordinated routine: one capsule with a meal, rather than organizing three products. Our recommendation is strongest for readers who have already established that this D3 amount is appropriate. The magnesium figure is 250 mg of L-threonate compound, not 250 mg elemental magnesium, and the ingredient trials are distinct from testing this exact finished formula.

Formulation strengths and limitations

What stands out

  • Three complementary nutrients in one daily capsule: D3, K2 as MK-7 and magnesium L-threonate.
  • Clearly stated D3 and K2 amounts, with 60- and 366-capsule options.
  • One capsule with a meal keeps the routine simple and easy to maintain.
  • The annual pack lowers the cost per capsule; BB10 offers an additional eligible-order saving.

Things to know first

  • 5,000 IU D3 is a high-potency dose: choose it when that amount suits your vitamin D plan.
  • 250 mg is magnesium L-threonate compound weight; the elemental magnesium amount is not separately declared.

Key takeaways

  • Our 5/5 editorial recommendation for adults seeking a convenient D3, MK-7 and magnesium L-threonate combination at this D3 strength.
  • Each capsule lists 125 micrograms D3 (5,000 IU), 120 micrograms K2 as MK-7 and 250 mg magnesium L-threonate.
  • Use the manufacturer’s one-capsule serving; taking extra capsules to increase magnesium also multiplies D3.
  • The 60-capsule pack lasts 60 days and the 366-capsule pack lasts 366 days at the labeled serving.
  • The ingredient research supports the nutritional rationale; a trial on this exact finished formula was not identified.
5/5 editorial recommendation D3 + MK-7 + L-threonate One daily capsule 60- and 366-capsule packs 131-paper Data Center BB10: 10% on eligible orders

Formulation

Key facts & composition

Serving 1 capsule daily DoNotAge recommends taking it with the last meal of the day.
Vitamin D3 125 micrograms / 5,000 IU per capsule A high-potency amount; total D3 from other supplements also counts.
Vitamin K2 120 micrograms as MK-7 A specific menaquinone form rather than an unspecified K2 blend.
Magnesium 250 mg magnesium L-threonate per capsule Compound weight. The manufacturer does not separately state elemental magnesium on the product page.
Pack sizes 60 capsules or 366 capsules 60 or 366 days at one capsule daily; annual subscription also offered.
US price snapshot $24 / 60 capsules; $114 / 366 capsules $0.40 or about $0.31 per day before discounts, tax and delivery. Source: manufacturer’s US listing, recorded 17 October 2026; checkout may change.
Capsule and dietary suitability Vegetable cellulose capsule; not vegan A plant-based capsule shell does not make the complete formula vegan.
Manufacturing GMP and ISO 9001 standards stated by DoNotAge Manufacturer quality guarantee. This review is a label and evidence assessment, not an independent assay of the current lot.

Composition

Ingredient Amount Form Source
Vitamin D3 125 micrograms (5,000 IU) Cholecalciferol DoNotAge product listing

D3 supplies the vitamin D component of this formula. The amount is above the 4,000 IU adult tolerable upper intake level for routine unsupervised use; a clinician may recommend higher intake for a specific reason. K2 does not cancel that limit.
Vitamin K2 120 micrograms Menaquinone-7 (MK-7) DoNotAge product listing

MK-7 is a well-studied K2 form with a relatively long circulating half-life. No universal D3-to-K2 ratio has been established. Discuss K2 with your anticoagulation team if you take warfarin or a similar vitamin K antagonist.
Magnesium L-threonate 250 mg compound Magnesium L-threonate DoNotAge product listing

Do not read this as 250 mg elemental magnesium or a full daily magnesium allowance. The EFSA assessment concerns specified L-threonate material and does not establish the elemental amount in this bottle. A product-specific label or batch document is needed for that figure.

Who this is for

Good fit if you're...

You want one capsule rather than three bottles

A convenient choice when all three fixed ingredient amounts suit your routine.

You have an appropriate plan for 5,000 IU D3

Best suited to someone who has a reason for this strength and will review their ongoing need.

You value a longer supply

A 366-capsule pack reduces reordering and lowers the listed cost per capsule.

Probably not for you if...

You only need a low-dose vitamin D top-up

A lower-dose D3 product gives you finer control than this high-potency combination.

You want a full-dose magnesium-only product

This is a combination capsule with 250 mg L-threonate compound, not 250 mg elemental magnesium.

You need a vegan formula or take warfarin

DoNotAge states this product is not vegan; vitamin K antagonists require professional guidance before changing K2 intake.

How it works

The appeal of this formula begins with complementary nutritional roles. D3 supports calcium absorption, K2 activates vitamin K-dependent proteins, and magnesium participates in vitamin D metabolism. The combination is easy to understand and easy to take. Biological compatibility gives a rationale for the formula; your need for each amount determines whether it is the right purchase.

1

D3 supports calcium absorption and vitamin D status

Vitamin D helps regulate calcium and phosphate balance and supports normal bone and muscle function. For someone whose vitamin D intake or status needs attention, a consistent D3 supplement can be useful. The reason to select this strength is an appropriate vitamin D plan, rather than a belief that the highest dose always gives the greatest benefit. See our vitamin D3 guide.

2

MK-7 complements the bone and calcium story

Vitamin K enables carboxylation of proteins including osteocalcin and matrix Gla protein. That gives D3 and K2 a coherent biological rationale together, and MK-7 is a useful, clearly identified form. “Supports normal calcium handling” is a more accurate expectation than assuming a capsule directs all calcium into bone or removes established plaque. Read the D3 and K2 guide.

Editorial close-up of the DoNotAge Pure D3, K2 and Magnesium jar.
3

Magnesium adds a complementary nutrient in a simple routine

Magnesium participates in enzyme systems involved in vitamin D metabolism and many other normal cellular processes. L-threonate is an interesting form because it also has human sleep and cognition research. Here it is a modest compound amount within a three-ingredient capsule. The main practical advantage is a coherent combination that removes the need to organize three bottles when these fixed amounts suit you. Pair the capsule with a regular meal and a magnesium-rich diet.

Editorial scene showing a DoNotAge D3, K2 and Magnesium jar beside an evening meal and water.

Research & evidence

16 cited sources · Vitamin D3, K2 & Magnesium Data Center

The evidence

Sources include research papers and other cited records, such as registered trials. A trial registration is not a published result.

Our 5/5 score is a product recommendation for its intended use. The grades below answer a different question: how strongly human research supports a particular health claim. B indicates reasonably supportive human evidence; C indicates limited or mixed findings. Tier 1 identifies human trials or their synthesis in our data center. None of the cited studies establishes clinical efficacy for this exact DoNotAge combination.

We selected 16 relevant papers from the 131-paper D3, K2 and Magnesium Data Center, including the 2026 calcification and cognition trials. Linked study records include doses, funding, limitations and relevant corrections.

B D3 and adequate magnesium can support vitamin D status Tier 1

A 12-week trial randomized 95 adults with overweight or obesity to D3 plus magnesium, D3 alone or placebo. The combined group had the largest rise in 25(OH)D, while inflammation and blood pressure did not show significant treatment effects. The magnesium form and dose differed from this product. A separate 180-person analysis found that magnesium’s effect on vitamin D metabolites depended on the starting level. The studies support addressing nutrient status, without establishing that every D3 user needs added magnesium.

May M Cheung et al. 2022 , Qi Dai et al. 2018 , Rosemary D Dall et al. 2023

C MK-7 has promising but mixed bone-health results Tier 1

In 244 postmenopausal women, 180 micrograms MK-7 daily for three years reduced bone loss at selected sites. Another three-year study in 142 women with osteopenia used 375 micrograms MK-7 alongside calcium and D3: vitamin K markers improved, but bone density and microarchitecture did not improve significantly. The product’s 120 micrograms is a different dose. This is a nutritional support choice rather than an osteoporosis treatment.

M H J Knapen et al. 2013 , S H Rønn et al. 2021

C The latest K2/D3 research supports interest in vascular calcification Tier 1

The 2026 DANCODE trial randomized 400 people with severe coronary calcification to 720 micrograms MK-7 plus 1,000 IU D3 daily or placebo for 24 months. In 398 analyzed participants, calcium scores still rose, but the average increase was smaller with supplementation: 196 versus 248 Agatston units. VitaK-CAC also reported slower progression with 360 micrograms MK-7. Earlier AVADEC findings were neutral for aortic-valve calcification, and its coronary analysis was neutral overall. These trials make the ingredient combination interesting; they do not show that this exact capsule reverses plaque or prevents heart attacks.

Selma Hasific et al. 2026 , Liv M Vossen et al. 2026 , Axel C P Diederichsen et al. 2022 , Selma Hasific et al. 2023

C L-threonate has an early human sleep signal at a higher compound dose Tier 1

An 80-person trial used 1 gram magnesium L-threonate daily for 21 days and reported improvements in selected sleep and daytime measures. It was industry funded and later had a corrigendum. One DoNotAge capsule lists 250 mg of the compound, one quarter of that study amount. The finding helps explain interest in the form, but it does not prove a sleep benefit from this serving. The linked research page includes the correction and study limitations.

Heather A Hausenblas et al. 2024

C Human cognition findings are encouraging and remain preliminary Tier 1

A 44-person trial in older adults used 1.5–2 grams daily of an L-threonate formulation for 12 weeks. A 2026 trial in 100 younger adults used 2 grams daily for six weeks and reported a small total-cognition signal; some individual tests and objective sleep measures were neutral. These were industry-linked ingredient studies, not trials of DoNotAge’s combination. The 2026 methods correction is linked in our research record. Do not increase this product to gram-level threonate doses, because D3 rises with every extra capsule.

Guosong Liu et al. 2016 , Adrian L Lopresti et al. 2026

B More D3 does not automatically mean stronger bones Tier 1

A three-year study comparing 400, 4,000 and 10,000 IU daily found no extra bone-strength benefit from the higher doses and greater loss of volumetric bone density at some sites. VITAL found no fracture reduction from 2,000 IU daily in a broad population not selected for deficiency. A meta-analysis of 3,200–4,000 IU trials also found a small absolute increase in hypercalcemia. These results support matching the dose to need, and distinguish correcting deficiency from giving higher doses to everyone.

Lauren A Burt et al. 2019 , Meryl S LeBoff et al. 2022 , Armin Zittermann et al. 2023

Label and research review dated 17 October 2026. The rating reflects formula, convenience and value for the intended user. Biohack Blueprint did not conduct a personal-use trial or independently assay the current retail lot.

Comparison

How it compares

DoNotAge Pure Vitamin D3, K2 & MagnesiumD3 + K2 only Three separate supplements
Daily organization Three nutrients in one capsule Two nutrients in one product; magnesium separate Each nutrient managed individually
D3 flexibility Fixed at 5,000 IU per capsule Depends on the formula selected Choose D3 strength independently
K2 form Clearly named MK-7, 120 micrograms Check whether MK-7 or MK-4 is used Select the K2 form and amount separately
Magnesium 250 mg L-threonate compound; elemental amount not separately stated Usually absent; check the label Choose the salt and a declared elemental amount
Supply and convenience 60- or 366-day pack at the labeled serving Pack and serving sizes vary Several packs and reordering schedules

Clinical pharmacology

Follow the manufacturer’s one-capsule serving with the last meal of the day when this strength suits your plan. At 5,000 IU, the D3 component is the main dosing decision. It is higher than standard public-health maintenance guidance and the 4,000 IU adult upper intake level for routine unsupervised use. A clinician may recommend a higher dose for a particular person, but a high-potency formula is not a reason to pursue the highest possible blood level.

Before buying, check the D3 already present in your multivitamin or other supplements, decide whether the fixed K2 amount suits your medicines, and distinguish the L-threonate compound amount from elemental magnesium. Our combined dosage guide walks through those decisions.

Dose tiers

TierDoseFrequencyDurationNotes
Manufacturer’s adult serving 1 capsule: 5,000 IU D3 + 120 micrograms MK-7 + 250 mg magnesium L-threonate Once daily with the last meal Review ongoing need with your clinician

Use this strength when appropriate for your vitamin D plan. Count D3 from multivitamins, cod liver oil and other supplements. If you need a lower D3 dose or more magnesium, choose separately adjustable products rather than multiplying this combination.

Drug interactions

Important

Warfarin and similar vitamin K antagonists

Changing vitamin K intake can alter anticoagulation control.

Recommendation:

Do not start, stop or change this K2-containing product without guidance from your anticoagulation team.

Separate dosing

Levothyroxine, certain antibiotics and oral bisphosphonates

Magnesium can interfere with absorption of some oral medicines.

Recommendation:

Ask a pharmacist for the interval required by your medicine. Follow your medicine’s specific spacing instructions; antibiotic requirements vary.

Review total intake

Thiazide diuretics and additional vitamin D or calcium

High D3 intake and some medicines can increase the risk of excessive blood calcium.

Recommendation:

Review your complete supplement and medication list with a clinician, especially with high calcium, kidney disease or a history of calcium-related problems.

Bioavailability tips

Take the capsule with a normal meal that contains some fat. This is practical for the fat-soluble vitamins D3 and K2; an elaborate timing protocol is unnecessary. DoNotAge suggests the final meal, but research does not establish one universally superior time. Keep the jar cool, dry and away from direct light, following the current label.

For reference, use the NIH vitamin D guidance, vitamin K guidance and magnesium guidance alongside the manufacturer’s instructions. If you need more magnesium, choose that dose independently rather than adding capsules of this high-D3 combination.

Special populations

PopulationRecommendationRationale
Adults with kidney disease or high blood calcium Clinician review before use

Kidney function affects magnesium handling, and vitamin D can affect calcium balance. The fixed combination may not suit the treatment plan.
Pregnancy, breastfeeding and children Choose an individually appropriate formula

This high-potency adult combination should not replace a prenatal or pediatric regimen. Ask the treating professional about the complete formula.
Adults already taking D3 or magnesium Add up all supplements first

Avoid accidental duplication. The magnesium L-threonate compound amount cannot be added to elemental-magnesium figures as though the units were equivalent.

Therapeutic positioning

DoNotAge earns our top recommendation within this use case because the formula makes a D3/K2/magnesium routine unusually straightforward. The clearly named nutrient forms and annual pack are its main selling points. A lower-dose D3 product or separate magnesium supplement can be a better match when your needs differ; that does not diminish the appeal of this combination for the reader it suits.

Value also depends on choosing the correct pack. The US manufacturer listing shows $24 for 60 capsules and $114 for 366 capsules, working out to $0.40 and approximately $0.31 per daily serving. Its annual 366-capsule subscription is listed at $78, approximately $0.21 per day. BB10 may reduce an eligible checkout total further; do not assume that every offer stacks. Prices were recorded on 17 October 2026 and exclude tax and delivery. A “from $24” headline refers to the smaller pack, not a 366-day supply.

A simple combined routine

Convenience Our preferred use case

Choose DoNotAge when the fixed D3 strength fits your plan and you value a single capsule with named MK-7 and L-threonate forms. This is the reason it receives our 5/5 editorial recommendation. You are buying a practical combination, not evidence that this exact bottle outperformed every alternative in a clinical trial.

Separately adjustable supplements

Dose flexibility Better when needs differ

Separate D3, K2 and magnesium products make sense when you need a lower D3 intake, a clearly quantified elemental magnesium dose, or magnesium at amounts closer to the sleep and cognition trials. Our combination supplement buying guide explains how to compare labels without mixing compound and elemental units.

Use the capsule alongside a varied diet, resistance and weight-bearing exercise, and appropriate medical care. Magnesium-rich foods still matter because this is not a full daily elemental-magnesium replacement. See our food-source guide for practical meals that complement the routine.

This food supplement does not replace osteoporosis treatment, cardiovascular care or an individualized deficiency regimen. Persistent symptoms deserve assessment rather than repeated dose increases.

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Reader questions

Is DoNotAge D3, K2 & Magnesium a good supplement?

Yes—our editorial rating is 5/5 for adults who want a convenient three-nutrient formula and for whom 5,000 IU D3 is appropriate. We particularly like the one-capsule routine, named MK-7 and L-threonate forms, and pack choices. The score is an editorial recommendation based on the formula and pack options, rather than a customer average or proof of clinical superiority.

What is in each capsule?

The manufacturer lists 125 micrograms vitamin D3, equivalent to 5,000 IU; 120 micrograms vitamin K2 as MK-7; and 250 mg magnesium L-threonate in a vegetable cellulose capsule. See the manufacturer’s current product listing for the latest label.

Does it provide 250 mg of elemental magnesium?

The product page describes 250 mg magnesium L-threonate and does not separately declare elemental magnesium. Those quantities are different. Do not count this as 250 mg elemental magnesium or assume it supplies a full daily magnesium requirement.

Is 5,000 IU D3 safe to take every day?

Some adults may be advised to use this amount, but it exceeds the 4,000 IU adult upper intake level for routine unsupervised intake. That limit is not a threshold at which toxicity suddenly begins. Use a reason for the dose, count other D3 products and review ongoing need with your clinician. See our D3 dosage guide.

When should I take it?

DoNotAge recommends one capsule with the last meal of the day. A meal containing some fat is a practical choice for D3 and K2. Consistency matters more than a precise clock time; a proven universal nighttime advantage has not been established. See our timing guide.

Can I take four capsules to get 1 gram of L-threonate?

No—do not use this combination that way. Four capsules would also provide 20,000 IU D3 and 480 micrograms K2. That is not the manufacturer’s serving. If you want a magnesium-only dose, select a separate product with an appropriate elemental-magnesium label.

Will this help sleep or memory?

Magnesium L-threonate has encouraging early human studies, generally using 1–2 grams of the compound daily. This formula supplies 250 mg per capsule, so the study results cannot be assumed at its serving. Treat it primarily as a convenient nutrient combination rather than a proven sleep or memory treatment.

Can it reverse arterial calcification?

That has not been established. DANCODE found slower progression in people with severe calcification using a different K2/D3 regimen, while other trials were neutral. Slower progression is different from removing existing calcium. Read our K2 and arterial calcification review.

Which pack offers better value?

In the manufacturer’s US listing recorded on 17 October 2026, 60 capsules were $24 and 366 capsules were $114: $0.40 versus about $0.31 per day at one capsule daily. The annual subscription was listed at $78, about $0.21 per day, with one annual 366-capsule shipment. These are price snapshots before tax, delivery or coupons; confirm the selected option and renewal terms at checkout.

Does BB10 work on this product?

BB10 is our DoNotAge reader code for 10% off eligible purchases. Follow our current code terms and checkout guide and check the final order total. Subscription eligibility, exclusions and combining offers depend on the current checkout terms.

Is the product vegan?

No. DoNotAge explicitly states that the finished product is not suitable for vegans, even though the capsule shell is vegetable cellulose.

Is the current bottle independently tested?

DoNotAge states that its products are made to GMP and ISO 9001 standards and provides its quality guarantee. Biohack Blueprint did not independently assay the current lot for this review. A batch-matched certificate is the appropriate document if you want to verify a particular bottle’s potency and contaminant testing.

What side effects or interactions should I consider?

Review the formula before use if you take warfarin or a similar vitamin K antagonist, have kidney disease or high blood calcium, or already use high-dose D3. Magnesium can interfere with absorption of certain medicines and can cause digestive upset. Persistent nausea, unusual thirst, frequent urination or weakness during high D3 intake warrant medical advice.

Do I need a vitamin D blood test?

Routine testing is not needed for every healthy adult. Because this product is a high-potency D3 formula, a clinician may use 25(OH)D and relevant calcium or kidney tests to guide its use when there is a clinical reason. Read our vitamin D blood-test guide.

Can I order it in the US, UK or Canada?

DoNotAge offers regional storefronts and international delivery. Prices, shipping thresholds, taxes and import conditions depend on destination and the selected store. Choose your region and confirm delivery at checkout; the US price snapshot above should not be treated as a UK or Canadian quote.

Editorial credibility

Portrait of Dr. Khaled Mahmoud, ICU physician and founder of Biohack Blueprint

Author

Dr. Khaled Mahmoud, MBBCh

MBBCh

Critical Care Medicine, Longevity Science & Editorial Direction

Portrait of Dr. Amr Yasser, cardiometabolic and musculoskeletal reviewer for Biohack Blueprint

Reviewer

Dr. Amr Yasser, PhD

MBBCh, PhD, General Surgery, Cardiometabolic Medicine, Musculoskeletal Research

Cardiometabolic, Musculoskeletal, Gut & Bioavailability

Portrait of Dr. Abdulla Mostafa, neuroscience reviewer for Biohack Blueprint

Reviewer

Dr. Abdulla Mostafa, PhD

MBBCh, PhD, Neuroscience, Neurosurgery

Cellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology

5/5 editorial rating for formula, convenience and value when 5,000 IU D3 suits your plan. Based on label and research review; not a customer average or hands-on trial.

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Related reading

Vitamin D3, K2 and Magnesium: Benefits, Doses and How to Choose

Vitamin D3, K2 and Magnesium Benefits: What Human Studies Show

Vitamin D3, K2 and Magnesium Dosage: Why There Is No Fixed Ratio

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Vitamin D3 Dosage: Daily Needs, 5,000 IU and Higher Doses

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  1. Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial Qi Dai, Xiangzhu Zhu, JoAnn E Manson, Yiqing Song, Xingnan Li, Adrian A Franke, Rebecca B Costello, Andrea Rosanoff, Hui Nian, Lei Fan, Harvey Murff, Reid M Ness, Douglas L Seidner, Chang Yu, Martha J Shrubsole (2018) . The American journal of clinical nutrition Read on our Data CenterView on PubMed View on PMC DOI Clinical Trial
  2. The effect of combined magnesium and vitamin D supplementation on vitamin D status, systemic inflammation, and blood pressure: A randomized double-blinded controlled trial May M Cheung, Rosemary D Dall, Patricia A Shewokis, Asma Altasan, Stella L Volpe, Renee Amori, Harpreet Singh, Deeptha Sukumar (2022) . Nutrition (Burbank, Los Angeles County, Calif.) Read on our Data CenterView on PubMed DOI Clinical Trial
  3. Combined vitamin D and magnesium supplementation does not influence markers of bone turnover or glycemic control: A randomized controlled clinical trial Rosemary D Dall, May M Cheung, Patricia A Shewokis, Asma Altasan, Stella L Volpe, Renee Amori, Harpreet Singh, Deeptha Sukumar (2023) . Nutrition research (New York, N.Y.) Read on our Data CenterView on PubMed DOI Clinical Trial
  4. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women M H J Knapen, N E Drummen, E Smit, C Vermeer, E Theuwissen (2013) . Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA Read on our Data CenterView on PubMed DOI
  5. The effect of vitamin MK-7 on bone mineral density and microarchitecture in postmenopausal women with osteopenia, a 3-year randomized, placebo-controlled clinical trial S H Rønn, T Harsløf, L Oei, S B Pedersen, B L Langdahl (2021) . Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA Read on our Data CenterView on PubMed DOI Clinical Trial
  6. Vitamin K2 and D3 Supplementation in Patients With Severe Coronary Artery Calcification: The DANCODE Trial Selma Hasific, Kristian Altern Øvrehus, Anna Mejldal, Susanne Hosbond, Jess Lambrechtsen, Preman Kumarathurai, Damini Dey, Emil Johannes Ravn, Lars Melholt Rasmussen, Oke Gerke, Hans Mickley, Axel Diederichsen (2026) . Circulation Read on our Data CenterView on PubMed DOI Clinical Trial
  7. Two Years of Menaquinone-7 Supplementation and Coronary Artery Calcification: A Randomized Clinical Trial Liv M Vossen, Peter W de Leeuw, Leon J Schurgers, Samuel Heuts, Bouke P Adriaans, Claudia de Haan, Bernard J van Varik, Abraham A Kroon (2026) . JAMA cardiology Read on our Data CenterView on PubMed View on PMC DOI Clinical Trial
  8. Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial Axel C P Diederichsen, Jes S Lindholt, Sören Möller, Kristian A Øvrehus, Søren Auscher, Jess Lambrechtsen, Susanne E Hosbond, Dilek H Alan, Grazina Urbonaviciene, Søren W Becker, Maise H Fredgart, Selma Hasific, Lars Folkestad, Oke Gerke, Lars Melholt Rasmussen, Jacob E Møller, Hans Mickley, Jordi S Dahl (2022) . Circulation Read on our Data CenterView on PubMed View on PMC DOI Clinical Trial
  9. Effects of Vitamin K2 and D Supplementation on Coronary Artery Disease in Men: A RCT Selma Hasific, Kristian A Oevrehus, Jes S Lindholt, Anna Mejldal, Damini Dey, Jordi S Dahl, Niels Erik Frandsen, Søren Auscher, Jess Lambrechtsen, Susanne Hosbond, Dilek Alan, Grazina Urbonaviciene, Søren Becker, Lars M Rasmussen, Axel P Diederichsen (2023) . JACC. Advances Read on our Data CenterView on PubMed View on PMC DOI
  10. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial Heather A Hausenblas, Tarah Lynch, Stephanie Hooper, Aahana Shrestha, Doug Rosendale, Jennifer Gu (2024) . Sleep medicine: X Read on our Data CenterView on PubMed View on PMC DOI
  11. The effects of magnesium L-threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial Adrian L Lopresti, Stephen J Smith (2026) . Frontiers in nutrition Read on our Data CenterView on PubMed View on PMC DOI
  12. Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial Guosong Liu, Jason G Weinger, Zhong-Lin Lu, Feng Xue, Safa Sadeghpour (2016) . Journal of Alzheimer's disease : JAD Read on our Data CenterView on PubMed View on PMC DOI
  13. Safety of magnesium l-threonate as a novel food pursuant to regulation (EU) 2015/2283 and bioavailability of magnesium from this source in the context of Directive 2002/46/EC EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch-Ernst, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Margarita Aguilera-Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Rosangela Marchelli, Monika Neuhäuser-Berthold, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Alexandros Siskos, Henk van Loveren, Wolfgang Gelbmann, Helle Katrine Knutsen (2024) . EFSA journal. European Food Safety Authority Read on our Data CenterView on PubMed View on PMC DOI
  14. Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength: A Randomized Clinical Trial Lauren A Burt, Emma O Billington, Marianne S Rose, Duncan A Raymond, David A Hanley, Steven K Boyd (2019) . JAMA Read on our Data CenterView on PubMed View on PMC DOI Clinical Trial
  15. Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults Meryl S LeBoff, Sharon H Chou, Kristin A Ratliff, Nancy R Cook, Bharti Khurana, Eunjung Kim, Peggy M Cawthon, Douglas C Bauer, Dennis Black, J Chris Gallagher, I-Min Lee, Julie E Buring, JoAnn E Manson (2022) . The New England journal of medicine Read on our Data CenterView on PubMed View on PMC DOI Clinical Trial
  16. Long-term supplementation with 3200 to 4000 IU of vitamin D daily and adverse events: a systematic review and meta-analysis of randomized controlled trials Armin Zittermann, Christian Trummer, Verena Theiler-Schwetz, Stefan Pilz (2023) . European journal of nutrition Read on our Data CenterView on PubMed View on PMC DOI
First published 17 Oct 2026 · Last verified 17 Oct 2026