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The effects of magnesium L-threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial
Frontiers in nutrition
2026
12:1729164
Bibliography
- PubMed
- PMID 41601871
- PubMed Central
- PMC12832366
- Funding
- Support is recorded from Threotech Inc.. See the original publication for grant and material-support details.
- Competing interests
- Threotech funded the trial, supplied the intervention and helped conceptualize its design. The authors disclosed employment or leadership roles in Clinical Research Australia and nutraceutical-industry research or honoraria.
Study snapshot
| Design | Randomized, double-blind, placebo-controlled trial |
|---|---|
| Model | Human participants |
| Sample | 100 adults aged 18–45 with dissatisfied sleep |
| Intervention | Magtein magnesium L-threonate 2 g/day, providing 145 mg/day elemental magnesium, or placebo |
| Duration | 6 weeks |
| Endpoints | Cognitive composite and memory; Sleep questionnaires and wearable sleep measures; Heart rate and variability |
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Key findings
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