Tier 1 — highest

The effect of combined magnesium and vitamin D supplementation on vitamin D status, systemic inflammation, and blood pressure: A randomized double-blinded controlled trial

May M Cheung, Rosemary D Dall, Patricia A Shewokis, Asma Altasan, Stella L Volpe, Renee Amori, Harpreet Singh, Deeptha Sukumar
Nutrition (Burbank, Los Angeles County, Calif.) 2022 99-100:111674

Bibliography

PubMed
PMID 35576873
DOI
10.1016/j.nut.2022.111674
Trial registry
View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding
Support is recorded from American Heart Association-American Stroke Association. See the original publication for grant and material-support details.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample95 adults with overweight or obesity randomized
InterventionMagnesium glycinate plus 1,000 IU vitamin D3; vitamin D3 alone; or placebo
Duration12 weeks
EndpointsSerum 25(OH)D; Parathyroid hormone; Blood pressure; Inflammatory markers

What the study showed, in plain terms

This publication examines serum 25(oh)d, parathyroid hormone, blood pressure, inflammatory markers. Study population or evidence base: 95 adults with overweight or obesity randomized. Intervention or exposure: Magnesium glycinate plus 1,000 IU vitamin D3; vitamin D3 alone; or placebo.

Key findings

Combined supplementation produced the largest increase in vitamin D status. A systolic blood-pressure improvement occurred in participants with higher starting pressure; parathyroid hormone and inflammation outcomes were not significantly improved.

What this study can and cannot tell us

A small, short trial in adults with overweight or obesity. The blood-pressure result came from a subgroup. Bone and metabolic outcomes from the same registered trial are reported separately.

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