Tier 1 — highest

Combined vitamin D and magnesium supplementation does not influence markers of bone turnover or glycemic control: A randomized controlled clinical trial

Rosemary D Dall, May M Cheung, Patricia A Shewokis, Asma Altasan, Stella L Volpe, Renee Amori, Harpreet Singh, Deeptha Sukumar
Nutrition research (New York, N.Y.) 2023 110:33-43

Bibliography

PubMed
PMID 36640582
DOI
10.1016/j.nutres.2022.12.005
Trial registry
View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding
Support is recorded from American Heart Association-American Stroke Association. See the original publication for grant and material-support details.
Competing interests
The publication includes author disclosures; consult the linked source for the individual relationships and their relevance.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample78 participants completed the three-arm intervention
Intervention1,000 IU/day vitamin D3 plus 360 mg/day magnesium as glycinate; D3 alone; or placebo
Duration12 weeks
EndpointsOsteocalcin and other bone-turnover markers; Glucose and insulin; HOMA-IR; Adiponectin

What the study showed, in plain terms

This publication examines osteocalcin and other bone-turnover markers, glucose and insulin, homa-ir, adiponectin. Study population or evidence base: 78 participants completed the three-arm intervention. Intervention or exposure: 1,000 IU/day vitamin D3 plus 360 mg/day magnesium as glycinate; D3 alone; or placebo.

Key findings

The combination raised vitamin D status but did not significantly improve bone-turnover markers, insulin resistance or glycemic measures compared with the other groups.

What this study can and cannot tell us

These are secondary biomarker outcomes from the same NCT03134417 intervention reported by Cheung and colleagues. They do not represent an independent trial or long-term fracture or diabetes outcomes.

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