Tier 1 — highest

Effects of Vitamin K2 and D Supplementation on Coronary Artery Disease in Men: A RCT

Selma Hasific, Kristian A Oevrehus, Jes S Lindholt, Anna Mejldal, Damini Dey, Jordi S Dahl, Niels Erik Frandsen, Søren Auscher, Jess Lambrechtsen, Susanne Hosbond, Dilek Alan, Grazina Urbonaviciene, Søren Becker, Lars M Rasmussen, Axel P Diederichsen
JACC. Advances 2023 2(9):100643

Bibliography

PubMed
PMID 38938724
PubMed Central
PMC11198368
DOI
10.1016/j.jacadv.2023.100643
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
The authors report no relevant competing interests.

Study snapshot

DesignSecondary analysis of a randomized, double-blind clinical trial
ModelHuman participants
Sample304 men without prior ischemic heart disease included in this analysis
Intervention720 μg/day vitamin K2 plus 25 μg/day vitamin D, versus placebo
Duration24 months
EndpointsCoronary artery calcium progression; Coronary plaque volume; Cardiovascular safety events

What the study showed, in plain terms

This publication examines coronary artery calcium progression, coronary plaque volume, cardiovascular safety events. Study population or evidence base: 304 men without prior ischemic heart disease included in this analysis. Intervention or exposure: 720 μg/day vitamin K2 plus 25 μg/day vitamin D, versus placebo.

Key findings

Mean coronary calcium progression was not significantly reduced overall. Signals in participants with greater baseline calcium scores and in safety events were exploratory findings requiring confirmation.

What this study can and cannot tell us

A secondary AVADEC analysis, not a new independent trial. Subgroup and safety-event findings should not override the neutral overall coronary-calcium result.

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