Tier 1 — highest
Vitamin K2 and D3 Supplementation in Patients With Severe Coronary Artery Calcification: The DANCODE Trial
Circulation
2026
:10.1161/CIRCULATIONAHA.126.082363
Bibliography
- PubMed
- PMID 42661461
- Trial registry
- View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
- Funding
- Funding attribution is not supplied in the indexed abstract; consult the linked original publication.
- Competing interests
- Consult the original publication for competing-interest declarations; the indexed record does not provide a concise declaration.
Study snapshot
| Design | Multicenter randomized double-blind placebo-controlled clinical trial |
|---|---|
| Model | Human participants |
| Sample | 400 participants randomized; 398 included in the intention-to-treat analysis; median age 71 years; 30% women |
| Intervention | 720 micrograms/day MK-7 plus 25 micrograms/day vitamin D3, versus placebo |
| Duration | 24 months |
| Endpoints | Coronary artery calcium-score progression; Coronary plaque composition in a CT angiography subset |
What the study showed, in plain terms
Key findings
What this study can and cannot tell us
Citation network
Articles citing this research paper
Biohack Blueprint analyses that reference this study in their evidence base.
- Vitamin K2 and Arterial Calcification: Can It Remove Plaque?DANCODE, VitaK-CAC and AVADEC compared: what K2 trials show about coronary calcium, plaque, progression and cardiovascular events.Read analysis
- Vitamin K2 MK-4 vs MK-7: Doses, Absorption and Human EvidenceCompare vitamin K2 MK-4 and MK-7 by circulating persistence, trial doses, bone and cardiovascular evidence, and product specifications.Read analysis
- Vitamin K2: Benefits, MK-7, Foods, Dosage and SafetyVitamin K2 explained: MK-4 and MK-7, bone and artery trials, food sources, dosage, labels and anticoagulant interactions.Read analysis
- Vitamin D3 and K2: Benefits, Dosage and Taking Them TogetherUnderstand D3 and K2 benefits, dose differences, bone and coronary-calcium trials, and whether the two need to be taken together.Read analysis
- Vitamin D3, K2 and Magnesium Dosage: Why There Is No Fixed RatioCalculate D3, K2 and magnesium doses, convert IU and micrograms, distinguish elemental magnesium, and account for other supplements.Read analysis
- Vitamin D3, K2 and Magnesium Benefits: What Human Studies ShowCompare D3, K2 and magnesium benefits for nutrient status, bones, arteries, sleep and cognition, with trial details and realistic limits.Read analysis
- Vitamin D3, K2 and Magnesium: Benefits, Doses and How to ChooseHow D3, K2 and magnesium work together, what human trials show, and how to compare doses, food sources, timing and combination supplements.Read analysis
Editorial review
Reviewed by the Biohack Blueprint research team
Last verified
