Tier 1 — highest

Two Years of Menaquinone-7 Supplementation and Coronary Artery Calcification: A Randomized Clinical Trial

Liv M Vossen, Peter W de Leeuw, Leon J Schurgers, Samuel Heuts, Bouke P Adriaans, Claudia de Haan, Bernard J van Varik, Abraham A Kroon
JAMA cardiology 2026 11(8):719-726

Bibliography

PubMed
PMID 42268593
PubMed Central
PMC13254800
DOI
10.1001/jamacardio.2026.1279
Trial registry
View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
The source discloses financial, employment, advisory or material-support relationships involving Gnosis. See the publication for the authors and nature of each relationship.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample180 patients with symptomatic coronary artery disease randomized
InterventionMK-7 360 μg/day or placebo
Duration2 years
EndpointsCoronary calcium score and mass; Coronary plaque characteristics; Adverse effects

What the study showed, in plain terms

This publication examines coronary calcium score and mass, coronary plaque characteristics, adverse effects. Study population or evidence base: 180 patients with symptomatic coronary artery disease randomized. Intervention or exposure: MK-7 360 μg/day or placebo.

Key findings

Coronary calcium accumulation was slower with MK-7 than placebo. The study provides a positive imaging signal in patients with established coronary disease.

What this study can and cannot tell us

The clinical meaning for plaque stability and cardiovascular events remains uncertain. This result does not demonstrate removal of existing calcium or prevention of heart attacks.

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