Tier 1 — highest

The effect of vitamin MK-7 on bone mineral density and microarchitecture in postmenopausal women with osteopenia, a 3-year randomized, placebo-controlled clinical trial

S H Rønn, T Harsløf, L Oei, S B Pedersen, B L Langdahl
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2021 32(1):185-191

Bibliography

PubMed
PMID 33030563
DOI
10.1007/s00198-020-05638-z
Trial registry
View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample142 postmenopausal women with osteopenia
InterventionMK-7 375 μg/day or placebo; both groups received calcium and vitamin D3
Duration3 years
EndpointsBone density; Bone microarchitecture; Osteocalcin carboxylation

What the study showed, in plain terms

This publication examines bone density, bone microarchitecture, osteocalcin carboxylation. Study population or evidence base: 142 postmenopausal women with osteopenia. Intervention or exposure: MK-7 375 μg/day or placebo; both groups received calcium and vitamin D3.

Key findings

MK-7 substantially improved osteocalcin carboxylation but did not significantly preserve bone density or microarchitecture over three years beyond calcium and vitamin D.

What this study can and cannot tell us

This is the longer-term report of the Danish osteopenia trial. Earlier one-year microarchitecture findings did not persist as clear between-group differences at three years.

Related papers in the corpus

Tier 1
Vitamin K2 (menaquinone-7) prevents age-related deterioration of trabecular bone microarchitecture at the tibia in postmenopausal women
Sofie Hertz Rønn et al. · European journal of endocrinology · 2016
Tier 1
Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women
M H J Knapen et al. · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013
Tier 1
Vitamin K2 supplementation does not influence bone loss in early menopausal women: a randomised double-blind placebo-controlled trial
N Emaus et al. · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2010
Tier 1
Effect of Low-Dose Vitamin K2 Supplementation on Bone Mineral Density in Middle-Aged and Elderly Chinese: A Randomized Controlled Study
Yingfeng Zhang et al. · Calcified tissue international · 2020
Tier 1
Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women
M H J Knapen et al. · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2007
Tier 1
Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women
Noriko Koitaya et al. · Journal of bone and mineral metabolism · 2014

Citation network

Articles citing this research paper

5 articles

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Biohack Blueprint Research